Common variants in CNDP1 and CNDP2, and risk of nephropathy in type 2 diabetes |
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| Authors: | T. S. Ahluwalia E. Lindholm L. C. Groop |
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| Affiliation: | (1) Department of Clinical Sciences—Diabetes and Endocrinology, Lund University Diabetes Centre, Clinical Research Centre (CRC), University Hospital Skane (UMAS), 20502 Malmo, Sweden |
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| Abstract: | ![]()
Aims/hypothesis Several genome-wide linkage studies have shown an association between diabetic nephropathy and a locus on chromosome 18q harbouring two carnosinase genes, CNDP1 and CNDP2. Carnosinase degrades carnosine (β-alanyl-l-histidine), which has been ascribed a renal protective effect as a scavenger of reactive oxygen species. We investigated the putative associations of genetic variants in CNDP1 and CNDP2 with diabetic nephropathy (defined either as micro- or macroalbuminuria) and estimated GFR in type 2 diabetic patients from Sweden. |
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