轻度认知功能障碍与neprilysin基因单核苷酸多态性的相关性

目的   分析轻度认知功能障碍（MCI）患者脑啡肽酶基因（NEP）rs3736187位点单核苷酸多态性，为MCI的防治提供理论依据。方法   参照美国精神病学会的精神障碍诊断和统计手册第4版（DSM-IV）的MCI诊断标准，应用聚合酶链反应-限制性片段长度多态性技术检测NEP基因多态性，采用病例-对照的关联分析方法，对NEP基因rs3736187位点进行基因型和等位基因频率分析。结果  NEP基因型频率和等位基因频率分布，MCI组与对照组间差异显著(P＜0.05)，T等位基因携带者出现MCI的危险性高于C等位基因携带者(OR=2.212, P＜0.05)，NEP基因基因型频率和等位基因频率分布，男性之间和女性之间差异不明显，女性MCI组与对照组间等位基因频率分布差异显著（P＜0.05）。结论   NEP基因的T等位基因可能是MCI的危险因素之一，在女性MCI的发病中可能起重要作用。

Association between mild cognitive impairment and neprilysin gene rs3736187 polymorphism

Objective To study the different distribution of the neprilysin(NEP) gene rs3736187 polymorphisms in patients with mild cognitive impairment(MCI) and normal healthy people.Methods 120 patients with MCI and 120 normal controls were examined with the neuropsychological test which included the mini-mental state examination(MMSE),activities of daily living scale(ADL),global deterioration scale(GDS) and Hachinski ischemic scale(HIS).NEP gene polymorphism was analyzed by PCR-restriction fragment length polymorphi...