| 姜黄素对急性肺动脉栓塞大鼠肺损伤及CFTR表达的影响 |
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| 引用本文： | 王征,玉寒冰,罗全. 姜黄素对急性肺动脉栓塞大鼠肺损伤及CFTR表达的影响[J]. 陕西肿瘤医学, 2014, 0(6): 1242-1244 |
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| 作者姓名： | 王征 玉寒冰 罗全 |
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| 作者单位： | 辽宁省肿瘤医院胸外科,辽宁沈阳110042 |
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| 基金项目： | 国家自然科学基金资助项目（编号：No：30901477/H0109） |
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| 摘 要： | 目的：观察姜黄素对急性肺栓塞大鼠肺损伤的保护作用及对CFTR表达的影响。方法：大鼠分为假手术组,模型组,姜黄素（150mg/kg）﹢APE组。制备左肺动脉结扎模拟急性肺动脉栓塞模型。进行血气分析,检测AFC及肺湿干比,real-time PCR方法检测肺组织的CFTR的表达。结果：与模型组比较,姜黄素升高PaO2水平,减轻AFC下降趋势,及减少肺湿干比的增加。姜黄素能提高肺组织的CFTR的表达。结论：姜黄素对急性肺动脉栓塞大鼠的急性肺损伤有保护作用,并上调CFTR的表达。
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| 关 键 词： | 姜黄素 急性肺动脉栓塞 急性肺损伤 CFTR |
Role of curcurmin in acute lung injury by acute pulmonary embolism and expression of CFTR |
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| Wang Zheng,Yu Hanbing,Luo Quan. Role of curcurmin in acute lung injury by acute pulmonary embolism and expression of CFTR[J]. Shaanxi Oncology Medicine, 2014, 0(6): 1242-1244 |
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| Authors: | Wang Zheng Yu Hanbing Luo Quan |
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| Affiliation: | (Thoracic Surgery Department ,Liaoning Tumor Hospital ,Liaoning Shenyang 110042, Chian.) |
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| Abstract: | Objective：To observe whether the curcumin could protect the acute lung injury by acute lung embolism and affect the expression of CFTR. Methods：SPF rats were divided into 3 groups：sham group,acute pulmonary em-bolism（APE）group and curcumin group（150mg/kg）. The model of acute pulmonary embolism was ligatured the left artery. Blood gas analysis,AFC and wet-to-dry ratio and CFTR mRNA expression were observed. Results：Curcu-min could increase artery O2 pressure,decrease the AFC downward and wet-to-dry ratio. Curcumin could increase the expression of CFTR mRNA. Conculsion：Curcumin could protect the acute lung injury by APE and associated with upward of CFTR mRNA. |
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| Keywords: | curcumin acute pulmonary embolism acute lung injury CFTR |
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