子宫内膜癌中错配修复蛋白表达缺失的意义

目的:评价MLH1、MSH2、PMS2和MSH6蛋白在子宫内膜癌中的表达缺失率,探讨MMR蛋白在子宫内膜癌发生、发展中的作用。方法:选取87例子宫内膜癌肿瘤组织,应用免疫组化方法检测子宫内膜癌组织中MLH1、MSH2、PMS2和MSH6蛋白的表达。结果:87例子宫内膜癌中MLH1、MSH2、PMS2和MSH6四种蛋白表达缺失率分别为12.6%(11/87)、2.3%(2/87)、16.1%(14/87)、6.9%(6/87),总的蛋白缺失率为31.0%(27/87)。MMR蛋白在不同年龄段的表达缺失率依次为:≤30岁为0%(0/2)、31-40岁为43.8%(7/16)、41-50岁为44.4%(12/27)、>50岁为19.0%(8/42)。I型子宫内膜样腺癌的MMR蛋白缺失率为36.9%,其中高级别的子宫内膜样腺癌中MMR蛋白表达缺失率为58.3%;II型子宫内膜癌中MMR蛋白的表达缺失率为13.6%。MMR蛋白在黏膜内癌、浅肌层浸润癌及深肌层浸润癌中的表达缺失率分别为14.3%(3/21)、29.6%(16/54)、66.7%(8/12),10例淋巴结转移的子宫内膜癌病例中有6例存在MMR蛋白的表达缺失。结论:MMR蛋白在低年龄段、高级别子宫内膜样腺癌、有深肌层浸润及淋巴结转移的子宫内膜癌病例中表达缺失率高,MMR蛋白在子宫内膜癌的进展中具有重要作用,建议临床常规检测子宫内膜癌中MMR蛋白的表达。

Delayed diuretic 18 F - FDG PET/CT scan for differentiating malignant from benign prostate lesions

Objective：To investigate the Potential value of delayed diuretic 18 F - FDG PET/ CT scan for differenti-ating malignant from benign Prostate hyPerPlasia. Methods：A total of 55 Patients with Prostate lesions underwent 18 F- FDG PET/ CT early - delayed imagings before transrectal needly bioPsy. After attenuation correction and iterative reconstruction,two PET data were analyzed semi - quantiatively by measuring maximum standardized uPtake values （SUVmax）in Prostate lesions. Results：16 cases of Prostate cancer and 39 cases of benign Prostate hyPerPlasis or chronic Prostatitis were confirmed by Pathological diagnosis. The statistical differences of benign and malignant lesions in SUVmax were significant. The sensitivity,sPecificity and accuracy of delayed diuretic 18 F - FDG PET/ CT scan were 68. 8%（11 / 16）,89. 7%（35 / 39）and 83. 6%（46 / 55）resPectively. Conclusion：Delayed diuretic 18 F - FDG PET/CT scan is a valuable non - invasive technology in the diagnosis of Prostate cancer. The SUVmax of Prostate lesions on delayed diuretic 18 F - FDG PET/ CT scan can imProve the diaglosis between benign and malignant.