| 姜黄素对急性坏死性胰腺炎大鼠核因子-κB活性的调节 |
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| 引用本文： | 陈垦,刘君君,龙友明,王晖,谢文瑞. 姜黄素对急性坏死性胰腺炎大鼠核因子-κB活性的调节[J]. 中药药理与临床, 2008, 24(6) |
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| 作者姓名： | 陈垦 刘君君 龙友明 王晖 谢文瑞 |
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| 作者单位： | 1. 广东药学院临床医学院,广州,510310
2. 广东药学院中药学院,广州,510006 |
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| 基金项目： | 广东省科学事业计划项目，广州市科学技术项目 |
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| 摘 要： | 目的:探讨姜黄素对急性坏死性胰腺炎(ANP)大鼠NF-κB活性的调节作用.方法:将SD大鼠随机分为胰腺炎组(ANP组)和姜黄素组(Cur组),通过分次腹腔注射10%L-精氨酸建立大鼠ANP模型,Cur组在造模前20天开始每天给予姜黄素灌胃.两组分别在造模后3h、12h、24h和36h处死大鼠,观察胰腺病理改变、NF-κB活性和血清淀粉酶、MDA、TNF-α、IL-1β的变化.结果:Cur组3h、12h、24h和36h时间点的与ANP组对应时间点比较,胰腺病理改变P=0.049,0.016,0.003:0.001;胰腺组织NF-κB活性P=0.001,0.001,0.006,0.001;淀粉酶P=0.043,0.001,0.002,0.001;丙二醛P=0.026,0.048,0.025,0.000;IL-1β P=0.016,0.016,0.002,0.006;TNF-α P=0.039,0.018,0.005,0.002.结论:姜黄素可能通过抑制NF-κB活性来下调细胞因子水平,并减轻胰腺损伤.
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| 关 键 词： | 姜黄素 急性坏死性胰腺炎 核因子-κB 细胞因子 |
Regulation effect of curcumin on NF-κB activity in rats with ANP |
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| Chen Ken,Liu Junjun,Long Youming,Wang Hui,Xie Wenrui. Regulation effect of curcumin on NF-κB activity in rats with ANP[J]. Pharmacology and Clinics of Chinese Materia Medica, 2008, 24(6) |
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| Authors: | Chen Ken Liu Junjun Long Youming Wang Hui Xie Wenrui |
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| Affiliation: | Chen Ken1,Liu Junjun1,Long Youming1,Wang Hui2,Xie Wenrui1(1 The Clinical College of Guangdong Pharmaceutical University,Guangzhou 510310,2 The Traditional Chinese Medicine College of Guangdong Pharmaceutical University,Guangzhou 510006) |
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