| 以EGFR家族受体酪氨酸激酶为靶点的抗肿瘤治疗研究进展 |
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| 引用本文： | 孔维佳,蒋建东.以EGFR家族受体酪氨酸激酶为靶点的抗肿瘤治疗研究进展[J].中国药理学通报,2003,19(8):847-851. |
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| 作者姓名： | 孔维佳 蒋建东 |
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| 作者单位： | 中国医学科学院·协和医科大学医药生物技术研究所,北京,100050 |
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| 基金项目： | 国家自然科学基金资助课题No 39870 889，39930 190 |
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| 摘 要： | 表皮生长因子受体 (EGFR)家族的受体酪氨酸激酶与多种恶性肿瘤的发生、发展及预后等密切相关。近年来 ,许多以此为靶点的新的抗肿瘤药物和治疗方法陆续被开发 ,主要有单克隆抗体、双特异性抗体、小分子酪氨酸激酶抑制剂和基因治疗等。它们有的已进入临床试验 ,耐受性良好 ,并且在多种肿瘤治疗中取得了令人鼓舞的疗效
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| 关 键 词： | EGFR家族 受体酪氨酸激酶 抗肿瘤治疗 单克隆抗体 双特异性抗体 酪氨酸激酶抑制剂 基因治疗 |
| 文章编号： | 1001-1978(2003)08-0847-05 |
| 修稿时间： | 2003年2月24日 |
Advances in anti-tumor therapy targeting the EGFR family of receptor tyrosine kinases |
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| KONG Wei-Jia,JIANG Jian-Dong.Advances in anti-tumor therapy targeting the EGFR family of receptor tyrosine kinases[J].Chinese Pharmacological Bulletin,2003,19(8):847-851. |
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| Authors: | KONG Wei-Jia JIANG Jian-Dong |
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| Abstract: | The epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases have close connection with the initiation, progression and progn osis of various malignancies. Recently, several approaches such as monoclonal an tibodies, bispecific antibodies, low molecular weight tyrosine kinase inhibitors and gene therapy targeting the EGFR family of receptors for anti-tumor therapy have been developed, some of which are currently undergoing clinical trials. Th ey are generally well tolerated, and have shown encouraging clinical efficacy in a variety of tumor types. |
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| Keywords: | EGFR family receptor tyrosine kinases anti-tumor the rapy monoclonal antibodies bispecific antibodies tyrosine kinase inhibitors gene therapy |
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