血清肿瘤坏死因子-α与冠状动脉病变程度的关系探讨

目的探讨血清肿瘤坏死因子-α(TNF-α)与冠状动脉病变程度的关系。方法选取冠心病患者101例作为观察组及健康体检者96例作为对照组。采用酶联免疫吸附剂测定(ELISA)法检测2组的血清TNF-α水平,采用改良的Gensini评分系数对冠状动脉病变程度进行评分。分析血清TNF-α与冠状动脉病变程度的关系。结果观察组TNF-α水平为(31.26±8.95)μg/L高于对照组的(14.33±2.55)μg/L,差异有统计学意义(P<0.05)。Gensini积分为5和11的患者TNF-α水平均高于积分为2的患者,差异均有统计学意义(P<0.05或P<0.01)。结论冠心病患者血清TNF-α水平高于健康者,并随着冠状动脉病变程度的增加而升高。

Discussion of relationship between serum tumor necrosis factor-a and coronary heart disease

Objective To explore the relationship between serum tumor necrosis factor-a（TNF-a）and coronary heart disease（CHD）. Methods 101 cases patients with CHD were set as observation group. 96 cases healthy peoples were set as control group. The serum TNF-a level was measured by enzyme-linked immunosorbent assay（ELISA）. Evaluated the severity of CHD by the improved Gensini score coefficient. Analyzed the relationship between serum TNF-a level and CHD. Results The TNF-a level of observation group was （31.26 ± 8.95 ） ug/L higher than （ 14.33 ± 2.55 ） ug/L of control group, the difference was statistically significant（P 〈 0.05）. The TNF-a of patients with Gensini scores of 5 and 11 were higher than the patients with scores of 2, the difference were statistically significant （ P 〈 0.05 or P 〈 0.01 ）. Conclusion The TNF-a level of patient with CHD is significantly higher than those in health people and is related to the atherosclerosis positively.