The expression of MHC antigens by human teratocarcinoma derived cell lines |
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| Authors: | P. W. Andrews D. L. Bronson M. V. Wiles P. N. Goodfellow |
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| Affiliation: | Wistar Institute for Anatomy and Molecular Biology, Philadelphia, Pennsylvania;Department of Urologic Surgery, College of Health Sciences, University of Minnesota, Minneapolis, Minnesota, U.S.A.;Imperial Cancer Research Fund, Lincoln's Inn Fields, London, England |
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| Abstract: | ![]()
We have used flow microflourimetry to investigate quantitatively the expression of HLA-A, B and C antigens, and β2 microglobulin, by cell lines derived from human teratocarcinomas. Although low levels of these cell surface molecules were expressed by all the lines examined, there was no evidence of discrete HLA-A, B, C/β2-microglobulin positive and negative subpopulations in any cultures. In contrast, using similar techniques, no murine embryonal carcinoma cell line was found to express the homologous H-2 antigens. It is suggested that human embryonal carcinoma cells may differ from their mouse counterparts by expressing low levels of major histocompatibility antigens. |
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