Functional pasta consumption in healthy volunteers modulates ABCG1-mediated cholesterol efflux capacity of HDL期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Functional pasta consumption in healthy volunteers modulates ABCG1-mediated cholesterol efflux capacity of HDL

Institution:	1. Department of Public Health Sciences, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA;2. The Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Albany, NY, USA;3. Monitoring Analytics and Therapeutic Care, Clinical Science Innovations, Philips Healthcare, Cambridge, MA, USA;4. Division of Biostatistics and Bioinformatics, Department of Family Medicine and Public Health, University of California, San Diego, CA, USA;5. Pediatrics and Chemistry at the Dell Medical School of the University of Texas at Austin, Austin, TX, USA;6. Cardiology Division, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA;1. Biochemistry and Molecular Biology Department, Biology Faculty, Barcelona University, Diagonal 643, 08028 Barcelona, Spain;2. Arnau de Vilanova University Hospital (UdL), Surgery Unit, Spain;3. Endocrinology and Nutrition Department at Arnau de Vilanova University Hospital (UdL) and Diabetes and Metabolism Research Unit (VHIR, UAB) and CIBER de Diabetes y Enfermedades Metabólicas (CIBERDEM) at the Instituto de Salud Carlos III, Spain;4. Biochemistry Department, Hospital Universitari Vall D''Hebron, Universitat Autònoma De Barcelona, Spain;5. Endocrinology Surgery Unit, Hospital Universitari Vall D''Hebron, Universitat Autònoma De Barcelona, Spain;1. LIFE – Leipzig Research Center for Civilization Diseases, Germany;2. University Leipzig, Germany;3. Department of Cardiology, Angiology and Intensive Care, Detmold, Germany;4. Klinikum Lippe, Detmold, Germany;5. Department of Internal Medicine/Cardiology, Germany;6. Heart Center University Leipzig, Germany;7. Institute of Medical Informatics, Statistics and Epidemiology, Germany;8. Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Leipzig, Germany;13. Pediatric Unit, “S. Maria delle Grazie”, Pozzuoli Hospital, Naples, Italy;14. Francesca Franco, Pediatric Unit, AOU Udine, Udine, Italy;15. IRCCS Istituto Auxologico Italiano, Obesity Unit and Laboratory of Nutrition and Obesity Research, Department of Endocrine and Metabolic Diseases, Milan, Italy;p. Pediatric Endocrine Unit, Pediatric Hospital for microcitemia, AO Brotzu, Cagliari, Italy;q. Institute for Maternal and Child Health IRCCS ‘Burlo Garofolo’, Trieste;1. Department of Internal Medicine, “S. Maria delle Grazie”, Pozzuoli Hospital, Naples, Italy;2. Policlinico Umberto I Hospital, Sapienza University of Rome, Rome, Italy;3. Obesity and Endocrine Disease Unit, Department of Neuroscience, Santobono-Pausilipon Children''s Hospital, Naples, Italy;4. Pediatric Diabetes and Metabolic Disorders Unit, University of Verona, Verona, Italy;5. IRCCS Bambino Gesù Children''s Hospital, Rome, Italy;6. Department of Woman, Child and General and Specialized Surgery, University of Campania “Luigi Vanvitelli”, Naples, Italy;7. Department of Cardiology, “S. Maria delle Grazie”, Pozzuoli Hospital, Naples, Italy;8. Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy;9. IRCCS Neuromed, Pozzilli, IS, Italy;10. Institute of Translational Pharmacology, National Research Council, Rome, Italy;11. Hypertension Research Centre, Department of Advanced Biomedical Sciences, Federico II University Hospital, Naples, Italy;12. Department of Movement Sciences and Wellbeing, University of Naples Parthenope, Naples, Italy;1. Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran;2. Department of Community Medicine, Tehran University of Medical Sciences, Tehran, Iran;1. Division of Prevention and Community Health, National Center for Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China;2. School of Public Health, Xi''an Jiaotong University, Xi''an, China;3. Department of Epidemiology, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of South China Structural Heart Disease, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China;4. Department of Epidemiology, National Center for Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China;5. Peking University Clinical Research Institute, Beijing, China

Abstract:	Backgrounds and aimsPrevention of cardiovascular (CV) disease is considered a central issue in public health and great attention is payed to nutritional approaches, including consumption of functional foods to reduce CV risk in individuals without indications for anti-atherosclerotic drugs. Cholesterol efflux capacity (CEC) is an important anti-atherogenic property of HDL and a marker of CV risk. We evaluated the effect of a daily consumption of an innovative whole-wheat synbiotic pasta, compared to a control whole-wheat pasta, on serum ATP binding cassette G1 (ABCG1)-mediated CEC in healthy overweight or obese individuals.Methods and resultsStudy participants (n = 41) were randomly allocated to either innovative or control pasta, consumed daily for twelve weeks. Serum CEC was measured before and after the dietary intervention, by a well-established radioisotopic technique on Chinese Hamster Ovary Cells transfected with human ABCG1. The innovative synbiotic pasta consumption was associated to a significantly higher post treatment/baseline ratio of ABCG1-mediated CEC values with respect to control pasta (mean ratio 1.05 ± 0.037 and 0.95 ± 0.042 respectively, p < 0.05). Analysis of the relationship between ABCG1-mediated CEC and glycemia, homocysteine, total folates and interleukin-6 showed specific changes in the correlations between HDL function and glycemia, oxidative and inflammatory markers only after synbiotic pasta consumption.ConclusionThis is the first report on serum CEC improvement obtained by a new synbiotic functional pasta consumption, in absence of lipid profile modifications, in overweight/obese participants. This pilot study suggests that a simple dietary intervention can be a promising approach to CV preservation through improving of athero-protective HDL function.

Keywords:	Functional food Synbiotic pasta Cardiovascular disease HDL function Cholesterol efflux CV"} {"#name":"keyword" "$":{"id":"kwrd0040"} "$$":[{"#name":"text" "_":"cardiovascular CEC"} {"#name":"keyword" "$":{"id":"kwrd0050"} "$$":[{"#name":"text" "_":"cholesterol efflux capacity ABCG1"} {"#name":"keyword" "$":{"id":"kwrd0060"} "$$":[{"#name":"text" "_":"ATP binding cassette G1 CVD"} {"#name":"keyword" "$":{"id":"kwrd0070"} "$$":[{"#name":"text" "_":"cardiovascular disease LDL-C"} {"#name":"keyword" "$":{"id":"kwrd0080"} "$$":[{"#name":"text" "_":"low density lipoprotein-cholesterol HDL-C"} {"#name":"keyword" "$":{"id":"kwrd0090"} "$$":[{"#name":"text" "_":"high density lipoprotein-cholesterol ABCA1"} {"#name":"keyword" "$":{"id":"kwrd0100"} "$$":[{"#name":"text" "_":"ATP-binding cassette A1 POFI"} {"#name":"keyword" "$":{"id":"kwrd0110"} "$$":[{"#name":"text" "_":"poliphenols and fibers POFI-SB"} {"#name":"keyword" "$":{"id":"kwrd0120"} "$$":[{"#name":"text" "_":"poliphenols and fibers enriched in Spores and B-glucans CRP"} {"#name":"keyword" "$":{"id":"kwrd0130"} "$$":[{"#name":"text" "_":"C-reactive protein IL-6"} {"#name":"keyword" "$":{"id":"kwrd0140"} "$$":[{"#name":"text" "_":"interleukin-6
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