| HPLC法测定醋酸曲安奈德搽剂的含量及有关物质 |
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| 引用本文： | 张磊. HPLC法测定醋酸曲安奈德搽剂的含量及有关物质[J]. 山东医药工业, 2014, 0(2): 87-89 |
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| 作者姓名： | 张磊 |
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| 作者单位： | 临沂市食品药品检验检测中心,山东临沂276000 |
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| 摘 要： | 目的 建立高效液相色谱法测定醋酸曲安奈德搽剂含量及有关物质的方法.方法 使用Capcell Pak C18（4.6mm×150 mm,5μm）,流动相为甲醇-水（70：30）,检测波长为240 nm,流速为1.0 mL·min^-1,柱温为30 ℃.结果 醋酸曲安奈德的线性范围为：5.170～51.70 μg·mL^-1（r=0.999 9）;平均回收率为102.90％,RSD为1.3％.结论 该方法简便,快速,准确,专属性强,可用于醋酸曲安奈德搽剂含量和有关物质的控制方法.
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| 关 键 词： | 醋酸曲安奈德 高效液相色谱法 含量测定 有关物质 |
Determination of triamcinolone acetonide and its related substances in Triamcinolone Acetonide Acetate Liniment by HPLC |
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| ZHANG Lei. Determination of triamcinolone acetonide and its related substances in Triamcinolone Acetonide Acetate Liniment by HPLC[J]. , 2014, 0(2): 87-89 |
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| Authors: | ZHANG Lei |
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| Affiliation: | ZHANG Lei ( Linyi Center for Food and Drug Testing, Linyi 276000, China ) |
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| Abstract: | Objective To establish a method for the determination of trialneinolone aeetonide and its related substances in Triamcinolone Acetonide Acetate Liniment. Methods A Capcell Pak C18 （4. 6 mm ×150 mm,5μm） column was adopt- ed with a lnobile phase of lnethanol - water（70：30） at the flow rate of 1.0 mL · min ^-1. The detection wavelength was 240 nm,and the eolunm temperature was 30 ℃. Results The linear range of triamcinolone aeetonide acetate was 5. 170 ～ 51.70μ g · mL ^-1 （r=0. 999 9 ）. The average recovery was 102. 90% ,and the RSD was 1.3%. Conclusion The proposed lnethod was silnple,rapid,accurate, repeatable,and can be used to control the quality of Trialncinolone Aeetonide Acetate Linilnent. |
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| Keywords: | Trismcinolone acetonide acetate HPLC Determination Rrelated substances |
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