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| 食管鳞癌组织VCAM-1和Survivin的表达及意义 | |
| 引用本文： | 杜媛鲲,王雷,李月牛,王娜,李莉. 食管鳞癌组织VCAM-1和Survivin的表达及意义[J]. 山东医药, 2008, 48(16): 1-2 |
| 作者姓名： | 杜媛鲲 王雷 李月牛 王娜 李莉 |
| 作者单位： | 河北医科大学,河北石家庄,050017;河北医科大学第四医院;河北井陉县中医院 |
| 基金项目： | 河北省卫生厅医学科研基金资助项目(2007118)。 |
| 摘 要： | 目的探讨血管细胞黏附分子1（VCAM-1）和Survivin与食管鳞癌细胞发生、发展与转移的关系。方法采用免疫组化法检测24例正常食管黏膜、94例食管鳞癌组织中Survivin和VCAM-1的表达情况。结果VCAM-1和Survivin在癌组织中的表达率明显高于正常食管黏膜，其中VCAM-1表达与淋巴结转移、浸润深度和临床分期等因素有关（P均〈0．05）；Survivin表达与浸润深度有关（P〈0．01）；VCAM-1和Survivin在癌组织中的表达无相关性。结论VCAM-1和Survivin在食管鳞癌中高表达，二者在食管鳞癌的发生、发展过程中具有重要作用，可作为评价食管鳞癌生物学行为的指标。 |
| 关 键 词： | 食管肿瘤 血管细胞黏附分子1 Survivin蛋白 |
Expression and clinical significance of VCAM-1 and Survivin proteins in esophageal carcinoma tissue |
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| DU Yuan-kun,WANG Lei,LI Yue-niu,WANG Na,LI Li. Expression and clinical significance of VCAM-1 and Survivin proteins in esophageal carcinoma tissue[J]. Shandong Medical Journal, 2008, 48(16): 1-2 | |
| Authors: | DU Yuan-kun WANG Lei LI Yue-niu WANG Na LI Li |
| Affiliation: | DU Yuan-kun1,WANG Lei,LI Yue-niu,WANG Na,LI Li(1 Hebei Medical University,Shijiazhuang 050017,P.R.China) |
| Abstract: | Objective To study the expression of VCAM-1 and Survivin in esophageal carcinoma and to investigate the relationship between the expression of VCAM-1,Survivin and carcinogenesis and progression of esophageal carcinoma.Methods VCAM-1 and Survivin expressions were detected in 24 normal esophageal mucosas,94 primary tumor tissues with immunohistochemistal method.Results The positive expression rate of VCAM-1 had the relationship with invasive depth,clinical staging and metastasis of lymph node(P<0.05).Survivin... |
| Keywords: | esophageal neoplasms vascular cell adhesion molecule-1 Survivin protein |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |