Use of phosphatidylcholine liposomes for correction of mitochondrial phospholipid composition in the medulla oblongata and frontal lobes in hemorrhagic shock

Phosphatidylcholine liposomes normalize phosphatidylcholine and lysophospholipid levels in mitochondrial membranes of the medulla oblongata of cats with hemorrhagic shock. In the frontal lobes of brain hemispheres of liposome-treated cats, phospholipid levels in the mitochondria and their membranes are close to the norm, with the exception of phosphatidylserine and lysophosphatidylserine: their contents in the inner mitochondrial membranes remain below the control. It is concluded that phosphatidylcholine liposomes exert protect brain mitochondrial membranes in hemorrhagic shock. Translated fromByulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 123, No. 4, pp. 374–377, April, 1997