血清C反应蛋白、铁蛋白与糖尿病视网膜病变严重程度关系的研究

目的探讨血清C反应蛋白（CRP）、血清铁蛋白（sF）水平和糖尿病视网膜病变（DR）严重程度的关系。方法随机选取住院的2型糖尿病患者60例，根据眼底检查结果分为无糖尿病视网膜病变组（M）R）21例、非增值期糖尿病视网膜病变组（NPDR）20例、增值期糖尿病视网膜病变组（PDR）19例。比较3组患者CRP、SF水平的关系。结果CRP、SF水平在NDR组、NPDR组、PDR组中逐渐升高，3者问比较差异有统计学意义（P〈0．05）。多因素有序logistic回归分析显示CRPSF是DR严重程度的独立危险因素。结论血清CRP、SF水平和DR严重程度密切相关，应重视早期监测血清CRP和SF。

Serum C- reactive protein, serum ferritin and its relationship with the severity of diabetic retinopathy

Objective To investigate serum C-reactive protein, serum ferritin and its rela- tionship with the severity of diabetic retinopathy. Methods According to the fundus examination, hospitalized patients with type 2 diabetes were randomly chosen and divided into three groups, in- cluding no diabetic retinopathy group （NDR group, n = 21）, non-proliferative diabetic retinopathy group （NPDR group, n = 20） and proliferative diabetic ertinopathy group （PDR group, n = 19）. The differences in the level of C-reactive protein and serum ferritin were analyzed. Results Total C -reactive protein, serum ferritin in NDR group, NPDR group and PDR group gradually increased, and the differences among three groups were statistically significant （P ~ 0.05）. Logistic multivari- ate regression analysis showed that C-reactive protein and serum ferritin were independent risk fac- tors of diabetic retinopathy. Conclusion The levels of C-reactive protein and serum ferritin which have some certain relationship with the severity of diabetic retinopathy should be monitored as early as possible.