The repressive effect of green tea ingredients on amyloid precursor protein (APP) expression in oral carcinoma cells in vitro and in vivo |
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| Authors: | Ko Shun-Yao Chang Kuo-Wei Lin Shu-Chun Hsu Hui-Chuan Liu Tsung-Yun |
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| Affiliation: | Department of Medical Research and Education, Veterans General Hospital-Taipei, Taipei, Taiwan, ROC. |
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| Abstract: | ![]()
In a hamster model of N-methyl-N-benzylnitrosamine (MBN)-induced oral carcinogenesis, the incidence of buccal pouch (HBP) carcinomas in MBN-treated hamsters (17.8+/-7.5) was significantly higher than MBN-treated hamsters given tea (10.8+/-3.9) (P<0.05). Amyloid precursor protein (APP) expression was also significantly increased in MBN-induced HBP carcinomas but was significantly reduced by tea intake (P<0.0001). Furthermore, APP expression and secretion by OECM-1 oral squamous cell carcinoma cells was inhibited by a major polyphenolic ingredient of green tea, (-)-epigallocatechin gallate, in a dose-dependent manner. Thus, APP might promote oral carcinogenesis, whereas green tea ingredients might diminish it by down-regulating APP. |
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| Keywords: | APP Cancer Carcinogenesis Mouth Tea APP" },{" #name" :" keyword" ," $" :{" id" :" cekeyw70" }," $$" :[{" #name" :" text" ," _" :" amyloid precursor protein EC" },{" #name" :" keyword" ," $" :{" id" :" cekeyw90" }," $$" :[{" #name" :" text" ," _" :" (−)-epicatechin ECG" },{" #name" :" keyword" ," $" :{" id" :" cekeyw110" }," $$" :[{" #name" :" text" ," _" :" (−)-epicatechin gallate EGC" },{" #name" :" keyword" ," $" :{" id" :" cekeyw130" }," $$" :[{" #name" :" text" ," _" :" (−)-epigallocatechin EGCG" },{" #name" :" keyword" ," $" :{" id" :" cekeyw150" }," $$" :[{" #name" :" text" ," _" :" (−)-epigallocatechin gallate GAPDH" },{" #name" :" keyword" ," $" :{" id" :" cekeyw170" }," $$" :[{" #name" :" text" ," _" :" glyceraldehyde 3-phosphate dehydrogenase HBP" },{" #name" :" keyword" ," $" :{" id" :" cekeyw190" }," $$" :[{" #name" :" text" ," _" :" hamster buccal paunch MBN" },{" #name" :" keyword" ," $" :{" id" :" cekeyw210" }," $$" :[{" #name" :" text" ," $$" :[{" #name" :" italic" ," _" :" N" },{" #name" :" __text__" ," _" :" -methyl-" },{" #name" :" italic" ," _" :" N" },{" #name" :" __text__" ," _" :" -benzylnitrosamine OSCC" },{" #name" :" keyword" ," $" :{" id" :" cekeyw230" }," $$" :[{" #name" :" text" ," _" :" oral squamous cell carcinoma PG" },{" #name" :" keyword" ," $" :{" id" :" cekeyw250" }," $$" :[{" #name" :" text" ," _" :" propylene glycol sAPP" },{" #name" :" keyword" ," $" :{" id" :" cekeyw270" }," $$" :[{" #name" :" text" ," _" :" secreted form of APP DMBA" },{" #name" :" keyword" ," $" :{" id" :" cekeyw290" }," $$" :[{" #name" :" text" ," _" :" 7,12-dimethylbenz[a]anthracene EGFR" },{" #name" :" keyword" ," $" :{" id" :" cekeyw310" }," $$" :[{" #name" :" text" ," _" :" epidermal growth factor receptor |
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