苦黄注射液与茵栀黄比较治疗病毒性肝炎的系统评价

目的系统评价苦黄与茵栀黄治疗病毒性肝炎的疗效以及安全性。方法电子检索Cochrane图书馆（2011年第1期）、EMBase（1974—2011）、PubMed（1978—2011）、VIP（1989—2011）、CBM（1978-2011）、CNKI（1978～2011）；手工检索相关杂志。纳入符合标准的随机对照试验（RCT），评价研究质量，提取有效数据，并用RevMan5．0软件进行Meta分析。结果最终纳入10个随机对照试验，Meta分析结果显示：苦黄在治疗病毒性肝炎时的总有效率比茵栀黄更高，且差异具有统计学意义[RR=1．30，95％CI（1．22，1．38），P〈0．00001]；苦黄与茵栀黄在治疗病毒性肝炎时有相似的不良反应发生率，且差异无统计学意义[OR：1．27，95％C1（0．33，4．89），P=0．73]。结论本系统评价结果显示，苦黄治疗病毒性肝炎的疗效优于茵栀黄，但因为纳入研究质量较低，尚需高质量，大样本，长期的随机对照试验加以验证。

Systematic review of kuhuang injection versus yinzhihuang in the treatment of viral hepatitis

Objective To evaluate the efficacy and safety of Kuhuang vs Yinzhihuang in the treatment of viral hepatitis. Methods We electronically searched The Cochrane Library （2011, issue 1 ）, EMBase （1974- 2011 ） , PubMed （1978- 2011 ）, VIP（ 1989 - 2011 ） , CBM （ 1978 - 2011 ）, CNKI （ 1978 - 2011 ） ; relevant magazines were also handsearched. Randomized controlled trails （RCTs） of Kuhuang Vs Yinzhihuang in the treatment of viral hepatitis which included were evaluated and analyzed by the software RevMan 5.0 . Results 10 studies were finally included. The result of Meta analysis demonstrated that Kuhuang was superior to Yinzhihuang in total effective rate in the treatment of viral hepatitis （ RR = 1.30, 95% CI （ 1.22, 1.38 ） , P 〈 0. 00001 ]. There was no statistically difference in incidence of overall adverse events （AEs） [OR ： 1.27, 95% CI（0. 33, 4. 89）, P = 0. 73 ]. Conclusion Kuhuang is effective and safe for viral hepatitis. The results suggest that further and larger-scale trials using Kuhuang for viral hepatitis.