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| 神经导管修复大鼠坐骨神经缺损实验研究 | |
| 引用本文： | 张凤久,赵志英,刘启,黄丽华. 神经导管修复大鼠坐骨神经缺损实验研究[J]. 包头医学院学报, 2010, 26(3): 14-16. DOI: 10.3969/j.issn.1006-740X.2010.03.006 |
| 作者姓名： | 张凤久 赵志英 刘启 黄丽华 |
| 作者单位： | 包头医学院人体解剖学教研室,内蒙古,包头014060;赤峰学院附属医院;包头医学院人体解剖学教研室,内蒙古,包头014060 |
| 摘 要： | 目的:采用一种自行研制的具有良好生物相容性的壳聚糖构建人工神经来修复大鼠坐骨神经缺损,研究证实其修复效果.方法:选用30只健康雄性Wistar大鼠,随机分为正常对照组(A组)、原位神经移植组(B组)、壳聚糖神经导管桥接组(C组)3组,分别切断坐骨神经后做相应处理,12周后进行神经电生理检测.结果:C组12周后神经已经长过缺损段,神经传导功能恢复.结论:这种套管能够有效的桥接10 mm长的大鼠坐骨神经缺损,可应用于周围神经缺损的治疗,同时可以作为进一步开发组织工程化的人工神经的良好载体. |
| 关 键 词： | 神经导管 周围神经 缺损 壳聚糖 |
An Experimental Study on the Repair of Sciatic Nerve Gap in Rats with Nerve Conduit |
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| ZHANG Fengjiu,ZHAO Zhiying,LIU Qi,et al. An Experimental Study on the Repair of Sciatic Nerve Gap in Rats with Nerve Conduit[J]. Journal of Baotou Medical College, 2010, 26(3): 14-16. DOI: 10.3969/j.issn.1006-740X.2010.03.006 | |
| Authors: | ZHANG Fengjiu ZHAO Zhiying LIU Qi et al |
| Affiliation: | ZHANG Fengjiu,ZHAO Zhiying,LIU Qi,et al (Department of Human Anatomy,Baotou Medical College,Baotou 014060,China) |
| Abstract: | Objective: Using a self-developed chitosan with good biocompatibility to build artificial nerves to repair defects in rat's sciatic nerve and a study was made to confirm the repair effect.Methods: 30 healthy male Wistar rats were randomly divided into 3 groups(A: normal control group,B: in situ nerve graft group,C: Artificial neural bridge group).Sciatic nerve were cut off with the deal accordingly,12 weeks later,the nerve electrophysiological testing was performed.Results:12 weeks later,the nerve has been ... |
| Keywords: | Nerve conduit Peripheral nerve Defect Chitosan |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |