Protective role of DDAH2 (rs805304) gene polymorphism in patients with myocardial infarction |
| |
| Authors: | Nonanzit Pérez-Hernández Gilberto Vargas-Alarcón Rocio Arellano-Zapoteco Nancy Martínez-Rodríguez José Manuel Fragoso Gad Aptilon-Duque Rosalinda Posadas-Sánchez Carlos Posadas-Romero Teresa Juárez-Cedillo María Lilia Domínguez-López José Manuel Rodríguez-Pérez |
| |
| Institution: | 1. Department of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico;2. Graduate Studies in Chemical–Biological Sciences, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City, Mexico;3. Department of Endocrinology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico;4. Epidemiologic and Health Service Research Unit, Aging Area, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico;5. Immunochemistry Laboratory, Department of Immunology, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, 11340 Mexico City, Mexico |
| |
| Abstract: | The purpose of the present study was to establish the role of DDAH gene polymorphisms in the risk of developing myocardial infarction (MI) in a clinical cohort of Mexican patients. One polymorphism (rs1498373) in the DDAH1 and three in the DDAH2 (rs805304, rs3131383, and rs805305) genes were performed by TaqMan genotyping assays in 473 patients with MI and 447 healthy unrelated controls. Similar distribution of DDAH1 and DDAH2 polymorphisms was observed in MI patients and healthy controls. Under a recessive model adjusted for age, gender, and obesity, the rs805304 C allele was associated with decreased risk of MI (OR = 0.70, 95% CI = 0.51–0.96, P = 0.030). The effect of the polymorphisms on various cardiovascular risk factors was analyzed. Under a recessive model adjusted for age and gender, the DDAH2 rs805304 C allele was associated with decreased risk of obesity (OR = 0.35, 95% CI = 0.22–0.57, P = 0.001). The three DDAH2 polymorphisms were in strong linkage disequilibrium. Our results suggest that the rs805304 C allele was associated with decreased risk of MI and decreased risk of obesity. |
| |
| Keywords: | Dimethylarginine dimethylaminohydrolase Polymorphisms Haplotypes Myocardial infarction |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
