Differential expression of anterior gradient protein 3 in intrahepatic cholangiocarcinoma and hepatocellular carcinoma |
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| Authors: | Veronika Brychtova Vita Zampachova Roman Hrstka Pavel Fabian Jiri Novak Marketa Hermanova Borivoj Vojtesek |
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| Affiliation: | 1. Regional Centre for Applied Molecular Oncology, Masaryk Memorial Cancer Institute, Zluty kopec 7, 65653 Brno, Czech Republic;2. First Department of Pathological Anatomy, Medical Faculty of Masaryk University and St. Anne''s University Hospital, Pekarska 53, 65691 Brno, Czech Republic;3. Department of Pathology, Masaryk Memorial Cancer Institute, Zluty kopec 7, 65653 Brno, Czech Republic;4. Department of Comprehensive Oncology Care, Masaryk Memorial Cancer Institute, Zluty kopec 7, 65653 Brno, Czech Republic |
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| Abstract: | Intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver cancer next to hepatocellular carcinoma (HCC). Despite the significant difference of the therapeutic strategy for both diseases, their histological appearance may be very similar. Thus the correct diagnosis is crucial for treatment choice but is often difficult to achieve. The aim of our study was to evaluate anterior gradient 3 (AGR3) as a new diagnostic marker helping to distinguish between ICC and HCC. AGR3 is a putative transmembrane protein implicated in breast, prostate and ovary tumorigenesis and belongs to the family of protein disulfide isomerases. |
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| Keywords: | ICC, intrahepatic cholangiocarcinoma HCC, hepatocellular carcinoma AGR3, anterior gradient 3 AGR2, anterior gradient 2 GPC-3, glypican-3 ROC, receiver operating characteristics AUC, area under curve |
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