间尼索地平与尼索地平对清醒兔血流动力学和局部血流量的影响

应用放射性生物微球技术观察间尼索地平(m-Nis)和尼索地平(Nis)对清醒兔血流动力学和局部血流量的影响。m-Nis 1μg/kg·min~(-1)×10min iv显著增加清醒兔CO、CI、SV和LVSW;等剂量Nis增加CO及CI不显著;两药对清醒兔MABP、HR和脑、心、肾、脾等局部血流量影响相似,对这些器官的血流分布及心输出量分布无明显影响。

EFFECTS OF M-NISOLDIPINE AND NISOLDIPINE ON THE HEMODYNAMICS AND REGIONAL BLOOD FLOW IN CONSCIOUS RABBITS

m-Nisoldipine ( m-Nis ) , isobutyl methyl 1 , 4-dihydro - 2, 6-dimethyl-4-( 3-nitrophenyl )-3 , 5-pyridine dicarboxylate, is a new calcium antagonist. Its effects on hemodynamics and regional blood flow as well as the distribution of cardiac output were evaluated in comparison with Nis with radio-biomicrospheres in conscious rabbits. ( 1 ) m-Nis ( 1 μg/kg · min-1 × 10 min, iv ) increased cardiac output and cardiac index significantly (P<0.05), while Nis at the same dose only slightly increased these parameters (P>0.05) ; ( 2 ) m-Nis increased stroke volume and left ventricular systolic work ( per beat ) while Nis slightly increased the former and decreased the later, and these differences were statistically significant (P<0.05) . ( 3 ) Both compounds were equally effective in decreasing mean arterial blood p-ressure, increasing regional blood flow and decreasing relative blood flow resistance of the brain, the heart and the spleen.