Experimental brain tumors by transplacental ENU |
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| Authors: | D. Schiffer M. T. Giordana A. Mauro G. Racagni F. Bruno S. Pezzotta P. Paoletti |
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| Affiliation: | (1) II. Neurological Clinic, University of Turin, v. Cherasco 15, I-10126 Turin, Italy;(2) Institute of Pharmacology and Pharmacognosy, University of Milan, Milan, Italy;(3) Neurosurgical Clinic, University of Pavia, Pavia, Italy |
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| Abstract: | ![]()
Summary Experimental cerebral tumors have been induced by transplacental ENU. The morphologic study of the brains of treated rats revealed that cellular hyperplasias appear at the 30th day of extrauterine life in the paraventricular white matter, i.e., before the already known  early neoplastic proliferations . Cytofluorimetric investigations failed to demonstrate differences between treated and control rats during the 1st month. On the contrary, adenylate cyclase activity is very high in that period. The duration of the latency period is discussed.This research was supported by Grants No. 79.00678.96 and No. 79.00664.96 of Progetto Finalizzato Control of Neoplastic Growth, Consiglio Nazionale delle Ricerche (C.N.R.), Rome |
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| Keywords: | ENU tumors Latency period |
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