Two new p-coumaroylated sesquiterpenoids from Pilea cavaleriei |
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| Authors: | Heng-Chun Ren Jun Zhang |
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| Institution: | 1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China;2. Beijing Increase Medicine Research Institute Co., Ltd., Beijing 102209, China |
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| Abstract: | A new p-coumaroylated santalane-type sesquiterpenoid, 8-p-coumaroyl-α-santalene (1), a new p-coumaroylated oplopanane-type sesquiterpenoid, 8-β-p-coumaroyl-oplopanone (2), and three known p-coumaroylated humulene-type sesquiterpenoids (3–5) were isolated from the ethanol extract of the whole herbs of Pilea cavaleriei. Their structures were elucidated based on the combination of 1D and 2D NMR and HRMS methods. Compound 2 was found to show anti-tuberculosis activity with MIC of 16 μg/ml. |
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| Keywords: | Pilea cavalerie Urticaceae 8-p-coumaroyl-α-santalene 8-β-p-coumaroyl-oplopanone structural elucidation anti-tuberculosis activity |
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