Triterpenoids with antioxidant activities from Myricaria squamosa |
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| Authors: | Heng Xu Zhen-Zhen Yuan Xiao Ma Chi Wang You-Rui Suo Hong-Lun Wang |
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| Institution: | 1. Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining 810008, China;2. University of Chinese Academy of Sciences, Beijing 100039, China;3. Key Laboratory of Plateau Ecology and Agriculture, Qinghai University, Xining 810016, China;4. Key Laboratory of Plateau Ecology and Agriculture, Qinghai University, Xining 810016, China |
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| Abstract: | A new triterpenoid, namely myricarin C (compound 1), together with three known compounds myricarin A (compound 2) and myricarin B (compound 3), 3α-hydroxy-D-friedoolean-14-en-28-oic acid (compound 4), was isolated from the overground part of Myricaria squamosa. Compound 2 and compound 3 existed in the solution by the form of cis-trans isomers. Their structures were elucidated by means of extensive spectroscopic methods, including 1D-NMR, 2D-NMR, and HR-ESI-MS. The antioxidant properties of all compounds were calculated based on the DPPH radical scavenging activities. Results showed that myricarin A and myricarin C had general antioxidant activities with EC50 values of 40.90 μg/ml, 42.22 μg/ml, respectively, compared to the control, rutin (5.17 μg/ml). The EC50 values of myricarin B was 195.81 μg/ml. Compound 4 had no antioxidant activities. |
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| Keywords: | Myricaria squamosa triterpenoid semi-preparative reversed phase liquid chromatography (RPLC) DPPH radical scavenging activity |
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