Cardioprotective effects of rutin in rats exposed to pirarubicin toxicity |
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| Authors: | Ya-Di Wang Yang Zhang Bo Sun Xiao-Wei Leng Ya-Juan Li |
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| Institution: | 1. Department of Pharmacology and Toxicology, School of Pharmacy, Jilin University, Changchun 130021, China;2. Department of Oncology, The Third Affiliated Hospital, Jinzhou Medical University, Jinzhou 121012, China |
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| Abstract: | We established both an acute and chronic cardiac toxicity rat model, which showed pretreatment with rutin attenuated pirarubicin-induced myocardial histopathological injury, electrocardiogram abnormalities, and cardiac dysfunction. Rutin also significantly reduced serum levels of MDA, BNP, CK-MB, CTnT, and LDH and increased serum SOD levels. Treatment with rutin and dexrazoxane resulted in an increase in Bcl-2/Bax ratio (p < 0.05) and reduction in JNK and Caspase-3 protein levels, compared to the pirarubicin group (all p < 0.05). Furthermore, rutin at a dose of 50 mg/kg significantly attenuated the above-mentioned alterations. Our study suggests the antioxidant and anti-apoptotic properties of rutin may be responsible for the cardioprotective effects observed. |
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| Keywords: | Rutin pirarubicin cardiotoxicity antioxidant anti-apoptotic |
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