| 聚丙交酯(PL)/丙交酯-聚乙二醇共聚物(PLEG)共混微球的制备、表征及释药行为 |
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| 引用本文： | 蒋宏亮,朱康杰. 聚丙交酯(PL)/丙交酯-聚乙二醇共聚物(PLEG)共混微球的制备、表征及释药行为[J]. 生物医学工程学杂志, 2000, 17(1): 5-9 |
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| 作者姓名： | 蒋宏亮 朱康杰 |
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| 作者单位： | 浙江大学,高分子科学与工程系,杭州,310027 |
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| 摘 要： | ＰＬ与ＰＬＥＧ是生物降解、生物相容的高分子材料，利用它们作为药物控释载体已引起人们广泛的重视。我们合成了含不同ＰＥＧ链段长度的ＰＬＥＧ共聚物，并利用ＰＬ与ＰＬＥＧ这两种材料各自的优点制备载有人绒毛促性腺激素（ｈＣＧ）的共混微球以提高ｈＣＧ在微球中的包埋率，结果表明采用Ｐ（Ｌ－ｃｏ－ＰＥＧ６０００）（９０：１０）与ＰＬ共混制备得到的微球中，ｈＣＧ的包埋率高于单独用ＰＬ或ＰＬＥＧ制得的微球。ｈＣＧ的体
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| 关 键 词： | 共混微球 药物控释载体 聚丙交酯 PLEG |
| 修稿时间： | 1998-05-26 |
Preparation, Characterization and Drug Release Characteristics of Poly(lactide)(PL)/Poly(lactide-co-polyethylene glycol)(PLEG) Blend Microspheres |
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| Jiang Hongliang,Zhu Kangjie. Preparation, Characterization and Drug Release Characteristics of Poly(lactide)(PL)/Poly(lactide-co-polyethylene glycol)(PLEG) Blend Microspheres[J]. Journal of biomedical engineering, 2000, 17(1): 5-9 |
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| Authors: | Jiang Hongliang Zhu Kangjie |
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| Affiliation: | Department of Polymer Science and Engineering, Zhejiang University, Hangzhou. |
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| Abstract: | PL and PLEG are biodegradable, biocompatible polymers. They have been widely used for controlled release of drugs. We synthesized PLEG copolymers containing PEG segments with various molecular weight and prepared hCG-loaded PL/PLEG blend microspheres to improve hCG entrapment efficiency. It was shown that the hCG entrapment effciency of PL/PLEG microspheres was higher than that of PL or PLEG microspheres when P(L-co-PEG6000)(90:10) was used. In vitro release test showed that the release of hCG was a burst-slow process, which was thought to be good for antigens to produce antibodies. |
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| Keywords: | Polylactide Poly(lactide-co-polyethylene glycol) Blend Microspheres Entrapment efficiency of protein |
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