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| N-糖基化修饰蛋白gp73与肝硬化患者Child-Pugh的关系 | |
| 引用本文： | 黄玉波,李鑫,乔雍,常路丝,肖凡,魏红莲,张仁雯,成军,魏红山. N-糖基化修饰蛋白gp73与肝硬化患者Child-Pugh的关系[J]. 胃肠病学和肝病学杂志, 2011, 20(4): 335-337 |
| 作者姓名： | 黄玉波 李鑫 乔雍 常路丝 肖凡 魏红莲 张仁雯 成军 魏红山 |
| 作者单位： | 1. 首都医科大学附属北京地坛医院,北京,100015 2. 首都医科大学附属同仁医医院 3. 北京大学医学部研究生院 |
| 基金项目： | 国家自然科学基金，北京市优秀人才培养专项经费资助项目 |
| 摘 要： | 目的评价N-糖基化修饰蛋白gp73的血清水平与肝硬化患者Child-Pugh之间的关系及其可能的临床意义。方法所观察的患者均为2009年1月~2010年10月在北京地坛医院门诊及住院肝硬化患者,所有患者均为HBsAg阳性。观察患者共610例,其中男性患者448例,年龄17~82岁,平均48岁;女性患者162例,年龄18~76岁,平均55岁。入组肝硬化患者的Child-Pugh分级主要依据血清白蛋白、总胆红素、凝血酶原活动度、腹水及肝性脑病评价等5项指标。血清gp73浓度采用ELISA法检测。结果伴随肝功能衰退,血清gp73水平也相应升高。血清gp73水平Child-Pugh为C级的患者（255.78 ng/mL±100.89 ng/mL）显著高于B级（203.30 ng/mL±99.15 ng/mL）和A级的患者（125.28 ng/mL±67.05 ng/mL）。血清gp73与白蛋白之间呈显著负相关（r=-0.52,P〈0.0001）。结论 HBV感染肝硬化患者血清gp73水平随肝功能恶化而升高。 |
| 关 键 词： | 肝硬化 高尔基体糖蛋白73（gp73） 肝功能 Child-Pugh分级 |
Relationship between N-glycosylated protein gp73 and Child-Pugh stage in cirrhotic patients |
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| HUANG Yubo,LI Xin,QIAO Yong,CHANG Lusi,XIAO Fan,WEI Honglian,ZHANG Renwen,CHENG Jun,WEI Hongshan. Relationship between N-glycosylated protein gp73 and Child-Pugh stage in cirrhotic patients[J]. Chinese Journal of Gastroenterology and Hepatology, 2011, 20(4): 335-337 | |
| Authors: | HUANG Yubo LI Xin QIAO Yong CHANG Lusi XIAO Fan WEI Honglian ZHANG Renwen CHENG Jun WEI Hongshan |
| Affiliation: | HUANG Yubo1,LI Xin1,QIAO Yong1,CHANG Lusi1,XIAO Fan1,WEI Honglian2,ZHANG Renwen3,CHENG Jun1,WEI Hongshan1 1.Beijing Ditan Hospital,Capital Medical University,Beijing 100015,2.Beijing Tongren Hospital,3.Academy of Postgraduate,Peking University Health Science Center,China |
| Abstract: | Objective To evaluate the relationship between serum concentration of gp73 and Child-Pugh stage in cirrhotic patients.Methods All subjects with HBsAg-positive were diagnosed as cirrhotic patients in Beijing Ditan Hospital,from January 2009 to October 2010.Total 610 subjects were included.The Child-Pugh score was based on albumin,total bilirubin,prothrombin activity,ascites and hepatic encephalopathy.Serum concentration of gp73 was determined by ELISA method.Results The serum concentration of gp73 in patient... |
| Keywords: | Liver cirrhosis gp73 Liver function Child-Pugh score |
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