| 泛素表达和蛋白酶体活性在胃癌及癌旁组织中的研究 |
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| 引用本文： | 蒲泽锦,李国平,冯家琳,吴灵飞. 泛素表达和蛋白酶体活性在胃癌及癌旁组织中的研究[J]. 胃肠病学和肝病学杂志, 2009, 18(11) |
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| 作者姓名： | 蒲泽锦 李国平 冯家琳 吴灵飞 |
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| 作者单位： | 1. 汕头大学医学院第二附属医院消化内科,广东,汕头,515041
2. 汕头大学医学院第二附属医院信息科,广东,汕头,515041 |
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| 摘 要： | 目的研究26S蛋白酶体水解活性及泛素在胃癌、癌旁组织与正常胃黏膜组织中的差异。方法对75例胃癌患者分别在胃癌、癌旁及远端正常黏膜组织取样进行研究。采用免疫印迹方法分析泛素表达,免疫荧光方法分析26S蛋白酶体活性。结果泛素表达及26S蛋白酶体活性在胃癌及癌旁组织中增强,均高于正常胃黏膜组织。胃癌中泛素水平(4.24vs3.27)及26S蛋白酶体活性(628.3vs431.8)均高于癌旁组织,差异有统计学意义。结论胃癌中泛素-蛋白酶体系统被异常活化,与胃癌的发生与进展有关。
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| 关 键 词： | 胃癌 泛素 蛋白酶体 |
The expression of ubiquitin and proteasome proteolytic activity in gastric cancer and adjacent tissues |
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| PU Zejin,LI Guoping,FENG Jialin,WU Lingfei. The expression of ubiquitin and proteasome proteolytic activity in gastric cancer and adjacent tissues[J]. Chinese Journal of Gastroenterology and Hepatology, 2009, 18(11) |
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| Authors: | PU Zejin LI Guoping FENG Jialin WU Lingfei |
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| Affiliation: | 1.Department of Gastroenterology; 2.Department of Information; the Second Affiliated Hospital; Medical College of Shantou University; Shantou 515041; China; |
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| Abstract: | Objective To study the expression of ubiquitin and 26S proteasome proteolytic activity in gastric cancer tissues,adjacent tissues and normal gastric mucosal tissues.Methods Gastric cancer tissues,adjacent tissues and normal gastric mucosal tissues in 75 patients were studied.The expression of ubiquitin and 26S protesome activity were analyzed by Western blot and fluorogenic technique,respectively.Results Compared with normal gastric mucosal tissues,the expression of ubiquitin and 26S proteasome proteolytic ... |
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| Keywords: | Gastric cancer Ubiquitin 26S proteasome |
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