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| 粪钙卫蛋白测定判断感染性腹泻的临床价值 | |
| 引用本文： | 白乌日娜,蒋琳,计春燕,黄平晓,陈志强,覃丽佳,谭诗云.粪钙卫蛋白测定判断感染性腹泻的临床价值[J].胃肠病学和肝病学杂志,2011,20(5):453-455. |
| 作者姓名： | 白乌日娜 蒋琳 计春燕 黄平晓 陈志强 覃丽佳 谭诗云 |
| 作者单位： | 1. 武汉大学人民医院消化内科,湖北,武汉,430060 2. 武汉大学人民医院检验科,湖北,武汉,430060 3. 湖北省新华医院 |
| 摘 要： | 目的探讨粪便钙卫蛋白（FCP）在腹泻鉴别诊断中的临床应用价值。方法感染性腹泻48例、腹泻型肠易激综合征（D-IBS）30例及正常对照组30例分别留取粪便5~10 g,用ELISA法检测粪便钙卫蛋白含量;同时收集患者病史及临床资料。结果感染性腹泻病人粪便钙卫蛋白检测值（515.21μg/g,n=48）显著高于D-IBS组（35.02μg/g,n=30）和正常对照组（25.18μg/g,n=30）（P〈0.001）。D-IBS组和正常对照组之间无明显差异（P〉0.05）。感染性腹泻FCP检测值与粪便显微镜下白细胞个数呈正相关（r=0.761）。设定FCP值100μg/g为临界值时判断感染性腹泻的检测敏感性为85.4%特异性为90.0%准确性为87.2%。结论 FCP有望用于感染性腹泻和非感染性腹泻的初步鉴别,具有快速、简便、准确率高、患者依从性好等优点,值得临床推广应用。 |
| 关 键 词： | 粪便钙卫蛋白 感染性腹泻 腹泻型肠易激综合征（D-IBS） |
Clinical value of fecal calprotectin in the diagnosis of infectious diarrhea |
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| BAI Wurina,JIANG Lin,JI Chunyan,HUANG Pingxiao,CHEN Zhiqiang,QIN Lijia,TAN Shiyun.Clinical value of fecal calprotectin in the diagnosis of infectious diarrhea[J].Chinese Journal of Gastroenterology and Hepatology,2011,20(5):453-455. | |
| Authors: | BAI Wurina JIANG Lin JI Chunyan HUANG Pingxiao CHEN Zhiqiang QIN Lijia TAN Shiyun |
| Institution: | BAI Wurina1,JIANG Lin2,JI Chunyan3,HUANG Pingxiao1,CHEN Zhiqiang1,QIN Lijia1,TAN Shiyun11.Department of Gastroenterology,2.Department of Laboratory,Renmin Hospital,Wuhan University,Wuhan 430060,3.Department of Gastroenterology,Xinhua Hospital,Hubei Province,China |
| Abstract: | Objective To explore the clinical value of fecal calprotectin in the differential diagnosis of infectious diarrhea.Methods Thirty people for health examination as controls,forty-eight patients with infectious diarrhea and thirty patients with diarrhea-predominant irritable bowel syndrome(D-IBS) were recruited.Stool sample(5~10 g) was collected in each people to determine fecal calprotectin by an emzyme-linked immunosorbent assay;meanwhile the case history and clinical data were collected simultaneously.Resu... |
| Keywords: | Fecal calprotectin Infectious diarrhea Diarrhea-predominant irritable bowel syndrome(D-IBS) |
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