| GAS7在人骨肉瘤中的表达及其意义 |
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| 作者姓名： | Hua Chen Jianchao Wang Jie Xie Jinsheng Li Fang Wang Shenghong Liu |
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| 作者单位： | [1]Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China [2]Department of Histology and Embryology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China |
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| 摘 要： | Objective： To detect the expression of GAS7 in osteosarcoma and discuss its significance. Methods： Immunohistochemistry SABC method was applied to detect GAS7 expression in specimens of 54 osteosarcoma and 15 osteochondroma cases. Results： The positive expression rate of GAS7 was 74.7% （40/54） in the group of osteosarcoma and 0% （0/15） in the group of osteochondroma. There was a significant difference in the comparison of GAS expression in these two groups （P 〈 0.05）. GAS7 was higher expressed in the samples which complicated with relapse or pulmonary metastasis than the control group （P 〈 0.05）. There was no significant association between GAS7 expression and the size of tumor, the gender or the age of the patients （P 〉 0.05）. Conclusion： The hyper-expression ot GAST may play an important role in the initiation and development of human osteosarcoma.
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| 关 键 词： | osteosarcoma GAS7 人骨肉瘤 表达 意义 osteosarcoma human significance play role initiation development gender patients association size of tumor complicated relapse pulmonary metastasis control significant |
| 文章编号： | 10.1007/s10330-007-0153-x |
| 收稿时间： | 2007-09-17 |
| 修稿时间： | 2007-12-12 |
GAS7 expression and its significance in human osteosarcoma |
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| Hua Chen Jianchao Wang Jie Xie Jinsheng Li Fang Wang Shenghong Liu.GAS7 expression and its significance in human osteosarcoma[J].The Chinese-German Journal of Clinical Oncology,2008,7(2):118-120. |
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| Authors: | Hua Chen Jianchao Wang Jie Xie Jinsheng Li Fang Wang Shenghong Liu |
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| Institution: | (1) Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China;(2) Department of Histology and Embryology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China |
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| Abstract: | Objective: To detect the expression of GAS7 in osteosarcoma and discuss its significance.Methods: Immunohistochemistry SABC method was applied to detect GAS7 expression in specimens of 54 osteosarcoma and 15 osteochondrema cases.Results: The positive expression rate of GAS7 was 74.7%(40/54)in the group of osteosarcema and 0%(0/15)in the group of osteochondroma.There was a significant difference in the comparison of GAS expression in these two groups (P＜0.05).GAS7 was higher expressed in the samples which complicated with relapse or pulmonary metastasis than the control group(P＜0.05).There was no significant association between GAS7 expression and the size of tumor, the gender or the age of the patients(P＞0.05).Conclusion: The hyper-expression of GAS7 may play an important role in the initiation and development of human osteosarcema. |
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| Keywords: | osteosarcoma GAS7 |
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