Influence of lecithin on some physical chemical properties of poloxamer gels: rheological, microscopic and in vitro permeation studies |
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| Authors: | Bentley M V Marchetti J M Ricardo N Ali-Abi Z Collett J H |
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| Institution: | 1. Department of Pharmaceutical Sciences, University of Sao Paulo, Avada do Café s/n, 14049-903, Ribeirão Preto, Brazil;2. Department of Chemistry, University of Ceará, Ceará, Brazil;3. Department of Pharmacy and Chemistry, University of Manchester, Oxford Road, M13 9PL, Manchester, UK;1. Department of Surgery, Faculty of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece;2. Laboratory of Pharmacology, Faculty of Medicine, Democritus University of Thrace, Alexandroupolis, Greece;3. Department of Gastroenterology, University Hospital of Heraklion, Heraklion, Greece;4. Department of Research and Development, Adilyfe Pty Ltd, Melbourne, Australia;1. Department of Dermatology, Mater Misericordiae University Hospital, Dublin, Ireland;2. Department of Dermatology, The Cleveland Clinic Foundation, Cleveland, Ohio;3. Department of Dermatopathology, The Cleveland Clinic Foundation, Cleveland, Ohio;1. The Casali Center for Applied Chemistry, The Institute of Chemistry, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Jerusalem 91904, Israel;2. Faculty of Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel;1. Université Paris Diderot, Sorbonne Paris Cité, Molécules Thérapeutiques In Silico, Paris, France;2. Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 973, Molécules Thérapeutiques In Silico, Paris, France |
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| Abstract: | Thermoreversible gels may be used in delivery systems which require a sol-gel transition at body temperature. The influence of the addition of lecithin, a permeation enhancer, on the rheological and in vitro permeation properties of poloxamer 407 gels was investigated. Light microscopy and rheological parameters were used to characterize the microscopic structure of the formulations which showed non Newtonian behaviour, pseudoplastic flow with a yield value. Increased concentrations of lecithin increased the thixotropy, yield value, apparent viscosity, and the gelation temperature of the gels. Light microscopy showed the formation of micellar structures by the addition of lecithin, which may account for changes in rheological properties. In vitro permeation of a model drug, triamcinolone acetonide, was decreased when the lecithin concentration was increased. The presence of lecithin in the poloxamer gel improved the characteristics for topical drug delivery. |
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