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白三烯拮抗剂孟鲁斯特钠联合舒利迭治疗老年哮喘的疗效
引用本文:谭立新,林燕梅,刘绍燕. 白三烯拮抗剂孟鲁斯特钠联合舒利迭治疗老年哮喘的疗效[J]. 国际医药卫生导报, 2012, 18(11): 1611-1613
作者姓名:谭立新  林燕梅  刘绍燕
作者单位:523770,东莞市大朗医院内一区
摘    要:
目的 探讨白三烯拮抗剂孟鲁斯特钠联合舒利迭治疗老年哮喘的临床疗效.方法 将我院老年哮喘患者62例随机分为两组,两组患者均给予常规治疗.对照组31例,在常规治疗基础上给予舒利迭雾化吸入治疗(每日2次,每次250μg);实验组31例,在常规治疗基础上给予白三烯拮抗剂孟鲁斯特钠(每晚1次,每次10 mg)联合舒利迭雾化吸人(每日2次,每次250μg)治疗,比较两组患者的治疗效果.结果 两组患者治疗后的症状和肺部功能均有明显效果(总有效率分别为90.32%、70.97%),其中实验组患者治疗后的临床症状与肺部功能改善更佳[一秒量( FEV1.0):(2.24±0.41)L vs.(1.92±0.27)L,一秒率(FEV1.0%):( 0.45±0.11)vs.(0.37±0.09),用力吸气峰流速(PEF):(4.55±0.12) L/s vs.(4.03±0.27) I/s],两组比较差异有统计学意义(P< 0.05).结论 白三烯拮抗剂孟鲁斯特联合吸入舒利迭治疗老年哮喘具有较好的治疗效果,值得在临床应用.

关 键 词:白三烯拮抗剂  孟鲁斯特钠  舒利迭  哮喘  高龄患者

Leukotriene antagonist montelukast sodium combined with seretide for senile asthma
TAN Li-xin , LIN Yan-mei , LIU Shao-yan. Leukotriene antagonist montelukast sodium combined with seretide for senile asthma[J]. International Medicine & Health Guidance News, 2012, 18(11): 1611-1613
Authors:TAN Li-xin    LIN Yan-mei    LIU Shao-yan
Affiliation:. Hospital of DMang County, Dongguan 523770, China
Abstract:
Objective To investigate the efficacy of leukotriene antagonist montelukast sodium combined with seretide in the treatment of senile asthma. Methods 62 elderly patients with asthma were randomly divided into two groups, and then received conventional treatment plus inhaled seretide of 250 μg twice daily ( 51 patients, control group ) or plus the same seretide combined with leukotriene antagonist montelukast sodium of 10 mg per night ( 31patients, study group ). The efficacy was compared between the two groups. Results After treatment, symptoms were markedly relieved and lung function was significantly improved in both groups ( 90.32% vs. 70.97% for the total effectiveness rate) symptom relief and improvement in lung function were more significant in the study group [FEV1.0(2.24 ± 0.41 ) Lvs. ( 1.92 ± 0.27) L, FEV1.0%: (0.45 ± 0.11 ) vs. (0.37 ± 0.09), PEF: (4.55 ± 0.12) L/ s vs. ( 4.03 ± 0.27 ) L/s ; P 〈 0.05]. Conclusions Combination therapy with leukotriene antagonist montelukast sodium and seretide for senile asthma has a better efficacy and is worth being applied clinically.
Keywords:Leukotriene antagonist  Montelukast  Seretide  Asthma  Elderly patients
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