法舒地尔预防神经介入术后脑血管痉挛的疗效观察

目的 观察法舒地尔在蛛网膜下腔出血患者介入治疗术后预防脑血管痉挛( CVS)的疗效.方法 将75例蛛网膜下腔出血行介入治疗患者随机分为两组,观察组(n=38):给予盐酸法舒地尔30 mg,3次/d,对照组(n=37):给予尼莫地平,1 mg/h,持续静脉泵入,两组疗程均2周,观察和比较两组治疗的总有效率.结果 观察组治疗总有效率(86.8％)明显高于对照组总有效率(67.6％)(P＜0.05),治疗过程中未出现严重不良反应.结论 法舒地尔在蛛网膜下腔出血行介入治疗后预防脑血管痉挛的疗效显著,安全可靠,值得临床推广应用.

The efficacy of fasudil in the prevention of cerebral vasospasm after neural interventional therapy

Objective To observe the clinical efficacy of fasudil in the prevention of cerebral vasospasm after neural interventional therapy. Methods 75 patients undergoing interventional therapy for subarachnoid hemorrhage were randomly divided into two groups. The study group （ n = 38 ） received fasudil hydrochloride of 30mg thrice daily for 2 weeks, while the control group （ n = 37 ） received intravenous nimodipine of 1 mg/h. The total effectiveness rate was observed and compared between the two groups. Results The total effectiveness rate of treatment group was higher in the study group than in the control group （ 86.8% vs. 67.6%, P 〈 0.05 ）. No serve adverse reactions occurred during the treatment. Conclusions Therapy with fasudil is efficacious and safe in the prevention of subarachnoid hemorrhage after neural interventional therapy and is worth popularizing clinically.