凯纷预防上腹部手术拔管期心血管反应的临床分析

目的研究氟比洛芬酯脂微球载体注射液(以下简称凯纷)预防上腹部手术拔管期心血管反应的临床应用,对其可行性进行评价。方法择期行上腹部手术患者80例,ASAⅠ~Ⅱ级。随机分成凯纷组(A组)和对照组(B)组,每组40例。手术结束前30 min,A组静脉注射凯纷50 mg,B组静脉注射生理盐水2.0 mL。记录麻醉前、拔管时、拔管后5 min、拔管后10 min时,HR、SBP、DBP、RR,观察躁动程度及恶心、呕吐等不良反应。结果 A组拔管时、拔管后5 min、拔管后10 min时的HR、SBP、DBP、RR较为平稳,明显优于B组(P<0.05)。A组拔管时,中重度躁动者少于B组(P<0.05)。两组恶心、呕吐症状无统计学差异。结论凯纷预防上腹部手术拔管期心血管反应,具有一定的可行性。

Flurbiprofen Axetil on Preventing Cardiovascular Reaction During Tracheal Extubation in Upper Abdominal Surgery

Objective To observe the effect of flurbiprofen axetil on preventing cardiovascular response during tracheal extubation in upper abdominal surgery and evaluate its feasibility.Methods Eighty patients（ASA Ⅰ～Ⅱ） undergoing upper abdominal surgery were randomly assigned into two groups（n=40 per group）： flurbiprofen axetil group（A） and control group（B）.At 30 min before the ending of surgery,the patients in Group A received intravenous injection of flurbiprofen axetil 50 mg and the patients in Group B received intravenous injection of saline 2.0 mL.HR,SBP,DBP and RR were recorded respectively at pre-anaesthesia,extubation,5 min and 10 min after extubation and the level of restness and adverse effect of nausea and emesia etc were observed at the same time.Results HR,SBR,DBP and RR in Group A were more stable than Group B（P0.05） at extubation,5 min and 10 min after extubation.The number of restness in middle and heavy degree in Group A was less than Group B（P0.05）.There was no significant difference between the two groups in the cases of nausea and emesia.Conclusion Flurbiprofen axetil on preventing cardiovascular response during tracheal extubation in upper abdominal surgery might be feasible.