| 乳腺癌他莫昔芬耐药机制的研究进展 |
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| 引用本文： | 于飞,胡晶,CHEN Xuesong. 乳腺癌他莫昔芬耐药机制的研究进展[J]. 实用肿瘤学杂志, 2017, 0(2): 160-164. DOI: 10.11904/j.issn.1002-3070.2017.02.013 |
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| 作者姓名： | 于飞 胡晶 CHEN Xuesong |
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| 作者单位： | 1. 哈尔滨医科大学附属肿瘤医院内四科 哈尔滨 150081;2. Department of Oncology,Harbin Medical University Cancer Hospital,Harbin 150081,China |
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| 基金项目： | 国家自然基金面上项目(81573001)，黑龙江省自然科学基金青年基金(QC2013C091) |
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| 摘 要： | 他莫昔芬(Tamoxifen,TAM)对于治疗雌激素受体(ER)阳性的乳腺癌是一种重要的治疗策略.然而TAM耐药是内分泌治疗失败的一个主要原因.TAM耐药的潜在机制是多因素的,其中大部分仍是未知的.本文介绍了近年来有关乳腺癌TAM耐药机制的研究进展,为阐明TAM耐药机理及克服耐药性提供有价值的信息和思路.
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| 关 键 词： | 他莫昔芬 乳腺癌 雌激素受体 耐药 |
Research progress of tamoxifen resistance mechanism in breast cancer |
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| YU Fei,HU Jing,CHEN Xuesong. Research progress of tamoxifen resistance mechanism in breast cancer[J]. Journal of Practical Oncology, 2017, 0(2): 160-164. DOI: 10.11904/j.issn.1002-3070.2017.02.013 |
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| Authors: | YU Fei HU Jing CHEN Xuesong |
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| Abstract: | Tamoxifen(TAM)is an important therapeutic strategy for the treatment of estrogen receptor(ER)-positive breast cancer.However,tamoxifen resistance is a major cause of endocrine therapy failure.The potential mechanism of TAM resistance is multifactorial and most of them are still unknown.This review presents recent advances in the mechanism of TAM resistance in breast cancer,providing valuable information and ideas for elucidating the mechanism of tamoxifen resistance and overcoming drug resistance. |
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| Keywords: | Tamoxifen Breast cancer Estrogen receptors Resistance |
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