不同发育天数囊胚冻融移植后妊娠结局分析

目的比较不同发育天数冻融囊胚移植后的妊娠结局。方法回顾性分析1 176例行冻融囊胚移植患者的临床资料,其中植入前遗传学诊断(preimplantation genetic diagnosis,PGD)周期135例,比较第5日单囊胚移植(single embryo transfer,SET)组、双囊胚移植(double embryo transfer,DET)组与第6日SET组和DET组的妊娠结局。结果同是优质囊胚级别的条件下,第5日DET组的生化妊娠率(56.91%)、临床妊娠率(53.25%)以及多胎妊娠率(1.20%)显著高于其他组(P0.05);第5日DET组与SET组的胚胎着床率无统计学差异(P0.05),但均显著高于第6日DET组和SET组(P0.05);同级别以及PGD周期中第5日和第6日SET组相比较,第5日组的生化妊娠率、胚胎着床率均显著高于第6日组(P0.05)。结论在同是优质囊胚的条件下,第5日SET、DET及经PGD诊断的SET妊娠结局均优于第6日。

Pregnancy outcome of frozen-thawed blastocyst transfers on different developmental days

Objective To compare the pregnancy outcomes of frozen-thawed blastocyst transfer on different developmental days.Methods Retrospective analysis was performed in the clinical data of 1 176 patients accepting frozen-thawed blastocyst transfer,including 135 cases in preimplantation genetic diagnosis (PGD) cycle.Those patients were sperated into two groups,single embryo transfer (SET) group and double embryo transfer (DET) group.The pregnancy outcomes in the two groups were compared on day 5 (D5) and D6.Results Biochemical pregnancy rate (56.91％),clinical pregnancy rate (53.25 ％) and multiple pregnancy rate (1.20％) in D5 DET were significantly higher than those in SET group (P＜0.05).There was no statistical difference in embryo implantation rate between D5 DET and D5 SET,while they were significantly higher than those m D6 DET group and SET group (P＜0.05).With the same level blastocysts and the blastocysts in PGD cycle between D5 and D6 SET in comparison,biochemical pregnancy rate,clinical pregnancy rate and embryo implantation rate in D5 group were significantly higher than those in D6 group (P＜0.05).Conclusion In frozen-thawed blastocyst transfer cycle,on the condition of all top-scoring blastocysts,pregnancy outcomes in D5 blastocyst transfer were better than those in D6 blastocyst transfer.