多发性骨髓瘤骨病的机制研究及治疗进展

多发性骨髓瘤是血液内科较常见的恶性疾病,其以恶性浆细胞在骨髓中过度增殖和积累为特征,产生大量单克隆免疫球蛋白及其片段,导致终末器官的损害.其中约80％的患者合并有多发性骨髓瘤骨病(MBD),从而严重影响了患者的生活质量及疾病预后.研究发现成骨细胞受抑、破骨细胞激活为其主要发病原因,而多种细胞因子及通路影响了这一机制的发生.本文就MBD发生、发展的最新因素及治疗做一综述.

Advarces in mechanism and treatment of multiple myeloma bone disease

Multiple myeloma is a more common malignant disease in blood medicine,which is characterized by hyper-proliferation and accumulation of malignant plasma cells in the bone marrow,resulting in a large number of monoclonal immunoglobulins and their fragments,leading to damage to the terminal organs.Of which about 80％ of patients have multiple myeloma bone diseases (MBD),which seriously affected the quality of life and prognosis of patients.We have found that the main cause of MBD are contributed to inhibition of osteoblasts,activation of osteoclast and affecting the occurrence by a variety of cytokines and pathways.This article will review and introduce the occurrence and development of MBD related to the latest factors and treatment.