Age-related reductions in rat atrial high affinity choline uptake, ACh synthesis, and ACh release. A brief note |
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| Authors: | E M Meyer A Esen Momol S P Baker |
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| Affiliation: | Department of Pharmacology and Therapeutics, University of Florida School of Medicine, J.H. Miller Health Center, P.O. Box J-267, Gainesville, FL 32610 U.S.A. |
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| Abstract: | ![]()
We have developed a rat atrial mince preparation that can take up choline, acetylate it, and then release acetylcholine in a depolarization-dependent manner. We demonstrate that aging appears to reduce the functional cholinergic activity in this tissue, which may be important for understanding how senescence alters the regulation of cardiac activity. |
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| Keywords: | Atria Choline-uptake Acetylcholine release |
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