医院铜绿假单胞菌375株耐药性分析

目的 探讨我院感染铜绿假单胞菌的耐药性,为临床合理用药提供依据.方法 采用法国生物梅里埃ATB Expression细菌鉴系统,用K-B纸片扩散法进行细菌耐药监测.结果 我院2010年9月至2011年9月共检出1030株革兰阴性细菌,其中铜绿假单胞菌有375株.铜绿假单胞菌对阿米卡星、头孢他啶和亚胺培南耐药率较低,分别为26.9％(101株)、35.2％(132株)和48.0％(180株),耐药率最高的为氨苄西林/舒巴坦和复方新诺明(100.0％),对头孢噻肟耐药率达96.9％(363株),对其他测试抗菌药物耐药率均在50％以上；铜绿假单胞菌分离率最高的病区为烧伤科病房,占37.6％(141株),其次为干部病房(22.9％).其余科室铜绿假单胞菌的分离率均低于10％.结论 铜绿假单胞菌是医院感染的主要革兰阴性菌,耐药性性严重,必须加强对铜绿假单胞菌的监测,以预防其在临床中的暴发和流行.

Analysis of nosocomial infection with 375 strains of pseudomonas aeruginosa and the approach of drugresistance

Objective To investigate the nosocomial infection and drug resistance of pseudomonas aeruginosa（PA） in our hospital to provide reference for the clinical rational use of drugs. Methods The microbiological ATB expression system was used to identify PA while the drug resistance was determined by K-B methods. Results Totally 1030 strains of gram-negative bacteria were isolated, among these PA was 375 strains. The highest rate of drug sensitivity of PA was amikacin （73.1%） ,followed by ceftazidime（64.8% ） and imipenem （52. 0% ）. The highest rate of drug-resistance of PA was ampicillin/sulbactam and cotrimoxazole （ 100. 0% ）. The ward of highest PA isolated rate was the burn ward （37. 6% ）, followed by cadre ward （22. 9% ）. The PA isolated rate of remaining sections was less than 10%. Conclusions PA is a major gram-negative pathogens of nosocomial infection and serious resistance of the branch. We should strengthen the monitoring of PA and make a great effort to prevent its outbreak.