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| 体外冲击波对大鼠肾脏损伤程度与重复处理间隔期间的关系 | |
| 引用本文： | 林宗明,缪中良,张永康,张元芳,章仁安,王国民,王晨曦. 体外冲击波对大鼠肾脏损伤程度与重复处理间隔期间的关系[J]. 复旦学报(医学版), 1995, 0(6) |
| 作者姓名： | 林宗明 缪中良 张永康 张元芳 章仁安 王国民 王晨曦 |
| 作者单位： | 上海医科大学中山医院泌尿科(林宗明，缪中良，张永康，张元芳，章仁安，王国民)，上海医科大学中山医院泌尿科(王晨曦) |
| 摘 要： | 应用大鼠孤立肾模型间隔不同期间重复体外冲击波处理,检测尿酶NAG活性、内生肌酐清除率及观察组织形态学变化,以研究体外冲击波(ESW)对肾脏损伤程度与重复处理的间隔期间关系。结果:第一次ESW处理后NAG显著升高,EC0显著降低;第二次ESW处理后,3d组和1周组NAG进一步显著升高,ECC进一步显著降低,而2周组、3周组和4周组上述生化指标均未见显著改变,组织学病变程度也较轻。结论:ESW冲击鼠肾可造成一定的肾实质损伤,重复ESW处理,其间隔期间小于1周时肾损伤较间隔期间大于2周时为重。本实验为肾结石病人进行重复体外冲击波治疗间隔期间的选择提供了实验资料,值得在临床实践中加以进一步研究与探索。 |
| 关 键 词： | 体外冲击波 肾损伤 大鼠孤立肾 肾结石 |
RELATIONSHIP BETWEEN RENAL INJURY CAUSED BY ESWL AND RE-ESWL INTERVAL TIME |
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| Lin Zongming,Miao Zhongliang,Zhang Yongkang,Zhang Yuanfang,Zhang Renan,Wang Guomin,Wang Chenxi. RELATIONSHIP BETWEEN RENAL INJURY CAUSED BY ESWL AND RE-ESWL INTERVAL TIME[J]. Fudan University Journal of Medical Sciences, 1995, 0(6) | |
| Authors: | Lin Zongming Miao Zhongliang Zhang Yongkang Zhang Yuanfang Zhang Renan Wang Guomin Wang Chenxi |
| Abstract: | Repeated ESWL treatments at different intervals on isolated kidney in rats were studied. The activity of urine NAG and endogenous creatinine clearance rate AS well as histological study of kidney were carried out for testing renal damage. The results indicated that the ESWL caused certain damage to renal parenchyma. The damage caused by repeated ESWL treatment in one-week intervals was more severe than that caused at more than two weeks intervals. This study makes a reference for selection of time interval between two successive ESWL treatment. |
| Keywords: | ESWL renal damage isolated kidney of rat renal calculi |
| 本文献已被 CNKI 等数据库收录！ | |