35例亚急性重症肝炎的超微结构分析

本文分析35例亚急性重症肝炎（简称亚重肝）的超微结构改变。其中病因有HBV 32例（91．4％），NANB1例（2．9％），HBV合并HDV1例（2．9％），未定2例，早期4例（11．4％），中期24例（68．6％），后期7例（20％），电镜下见大片肝细胞坏死，为炎症细胞取代，残存及再生肝细胞均呈不同程度的变性，浆内出现灶性及融合性液化区，细胞器严重损害，尤以线粒体及内质网为甚。作者认为光镜和电镜结合观察，是研究亚重肝形态改变的重要手段。

ULTRASTRUCTURAL CHANGES OF HEPATOCYTES IN SUBACUTE SEVERE HAEATITIS

The ultrastructural changes in liver cells were analysed in 35 cases of subacute viralfulminant hepatitis.Among them,32 cases were HBV,one was NANB and the etiology ofother two were uncertain.Only one case of HBV was accompanied by HDV.Apart frommassive confluent necrosis,most of the hepatocytes showed swelling of the mitochondriawith reduction in the density of mitochondrial matrix,and dilated or vesiculated endoplasmicreticulum with disaggregation of polyribosomes.These events began with a virushepatocyteinteraction that involved primary damage to the cell membrane,cyte organelles,mostlyreversible.