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| 日本血吸虫成虫抗原合并蚯蚓抗原对小鼠胸腺淋巴细胞及亚群的影响 | |
| 引用本文： | 姜昌富,贺宇飞,于爽,孙焱. 日本血吸虫成虫抗原合并蚯蚓抗原对小鼠胸腺淋巴细胞及亚群的影响[J]. 中国人兽共患病杂志, 1999, 27(4) |
| 作者姓名： | 姜昌富 贺宇飞 于爽 孙焱 |
| 作者单位： | 同济医科大学人体寄生虫学教研室，同济医科大学第二临床学院 |
| 摘 要： | ＢＡＬＢ／ｃ小鼠经可溶性日本血吸虫成虫抗原（ＳＷＡＰ）或／和可溶性蚯蚓抗原（ＳＥＷＰ）免疫后，观察、计数其胸腺Ｔ细胞总数、活性Ｔ细胞、Ｌ３Ｔ４细胞以及Ｌｙｔ２细胞。结果显示，ＳＷＡＰ免疫组Ｌ３Ｔ４细胞明显增加（Ｐ＜０．０５）；ＳＥＷＰ免疫组４个指标则均无明显变化（Ｐ＞０．０５）；ＳＷＡＰ与ＳＥＷＰ混合制剂免疫组Ｔ细胞总数、活性Ｔ细胞以及Ｌ３Ｔ４细胞均显增加（Ｐ＜０．０５）。相关分析表明：ＣＤ＋４Ｔ细胞（即Ｌ３Ｔ４细胞）在ＳＷＡＰ所诱导的保护性免疫力中可能起重要作用，而ＳＥＷＰ存在细胞免疫以外的其它可能保护性免疫机制，但ＳＥＷＰ与ＳＷＡＰ有明显的协同作用 |
| 关 键 词： | 日本血吸虫 可溶性成虫抗原 蚯蚓抗原 胸腺淋巴细胞 |
EFFECTS OF SCHISTOSOMA JAPONICUM WORM ANTIGEN AND EARTHWORM ANTIGEN ON THYMOCYTE AND SUBPOPULATION IN MICE |
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| Jiang ChangfuHe YufeiYu Shuanget al. EFFECTS OF SCHISTOSOMA JAPONICUM WORM ANTIGEN AND EARTHWORM ANTIGEN ON THYMOCYTE AND SUBPOPULATION IN MICE[J]. Chinese Journal of Zoonoses, 1999, 27(4) | |
| Authors: | Jiang ChangfuHe YufeiYu Shuanget al |
| Abstract: | To investigate Total thymocytes,active thymocytes,L3T4 cells and Lyt2 cells in BALB/c mice after being immunized with soluble S.japonicum worm antigen preparations(SWAP) or/and soluble earthworm preparations(SEWP).L3T4 cells were significantly increased in SWAP immunized group( P <0.05).No obvious changes happened in SEWP group.While total thymocytes,active thymocytes and L3T4 cells were all significantly increased ( P <0.05)in SWAT-SEWP jointly immunized group.The results suggest that CD4 cells(i.e.L3T4 cells) might play an important rele in the protective immunity elicited by SWAP,whereas SEWP have other possible protective immunity mechanisms.but there is obvious synergism between SEWP and SWAP. |
| Keywords: | Schistosoma japonicum Soluble worm antigenEarthworm antigenTymocyte |
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