联合检测肿瘤标志物在胸腔积液中的应用价值

目的探讨胸腔积液中肿瘤标志物癌胚抗原（carcinoe mbronic antigen,CEA）、细胞角蛋白19片断（cytok-eratin fragment21-1,CYFRA21-1）、神经元特异性烯醇化酶（neuron specifi cenolase,NSE）检测在胸腔积液诊断中的价值。方法应用电化学发光法对65例肺癌患者和28例良性对照者的血清和胸腔积液进行检测。结果肺癌组中血清和胸水肿瘤标志物明显高于对照组（P〈0.01）;肺癌组胸水三项指标高于血清水平（P〈0.01）;CEA对肺腺癌,NSE对小细胞肺癌,CYFRA21-1对肺鳞癌的阳性率高于其它单项（P〈0.05）。结论胸腔积液CEA、NSE、CYFRA21-1检测有助于肺癌的诊断。

Clinical Application of Combined Detection of Tumor Markers in Pleural Effusion

Objective To investigate the diagnostic value of tumor markers including carcinoembronic antigen （CEA）,neuron specific enolase （NSE） and cytokeratin fragment 21-1 （CYFRA21-1） in pleural effusion.Methods Serum and pleural effusion of 65 patients with lung cancer and 28 benign controls were tested by electrochemiluminescence.Results In serum and pleural effusion of lung cancer group,the values of tumor marker were significantly higher than those in control group （P0.01）.For the cancer group,the levels of three indicators in pleural effusion were higher than those in the serum （P0.01）.The positivity rates of CEA in lung adenocarcinoma,of NSE in small cell lung cancer and of CYFRA21-1 in lung squamous cell carcinoma were higher than any other indicators （P0.05）.Conclusion Detection of CEA,NSE and CYFRA21-1 in the pleural effusion is helpful for the diagnosis of lung cancer.