Nerve, muscle and heart acute toxicity following oxaliplatin and capecitabine treatment |
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Authors: | Orsucci Daniele Pizzanelli Chiara Alì Greta Calabrese Rosanna Ricci Giulia Lenzi Paola Petrozzi Lucia Moretti Policarpo Siciliano Gabriele |
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Affiliation: | Department of Neuroscience, Neurological Clinic, University of Pisa, Via Roma 67, 56126 Pisa, Italy. d.orsucci@sssup.it |
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Abstract: | Capecitabine plus oxaliplatin combination (XELOX) is the first-line treatment in metastatic colorectal cancer. Here we report a case of acute, severe but substantially reversible, neuromuscular and cardiac toxicity following XELOX chemotherapy. Muscle biopsy findings were consistent with a toxic myopathy with necrotizing features and vacuolar changes; COX-negative fibers were also present. The time course could support a main role for capecitabine, which may have some neurotoxic effects (more frequently central), but a detrimental interaction between the two drugs cannot be ruled out and further studies are needed. |
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