Localization of 125I-insulin binding sites in the rat hypothalamus by quantitative autoradiography |
| |
| Authors: | E S Corp S C Woods D Porte D M Dorsa D P Figlewicz D G Baskin |
| |
| Affiliation: | 1. Department of Psychology, University of Washington, Seattle, WA 98195 U.S.A.;2. Department of Medicine, University of Washington, Seattle, WA 98195 U.S.A.;3. Department of Biological Structure, University of Washington, Seattle, WA 98195 U.S.A.;4. Department of Pharmacology, University of Washington, Seattle, WA 98195 U.S.A.;5. the Veterans Administration Medical Center, Seattle, WA 98108 U.S.A.;1. Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA;2. Department of Comparative Pathobiology, Purdue University, West Layfette, IN 47907, USA;1. Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA;2. Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA;3. Department of Biostatistics, University of Iowa, Iowa City, IA 52242, USA;4. Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242, USA;5. Department of Pathology, University of Iowa, Iowa City, IA 52242, USA;6. Department of Epidemiology, University of Iowa, Iowa City, IA 52242, USA;7. Veterans’ Affairs Medical Center, Iowa City, IA 52242, USA;8. Infectious Disease Research Institute, Seattle, WA 98102, USA |
| |
| Abstract: | ![]()
In vitro autoradiography and computer video densitometry were used to localize and quantify binding of 125I-insulin in the hypothalamus of the rat brain. Highest specific binding was found in the arcuate, dorsomedial, suprachiasmatic, paraventricular and periventricular regions. Significantly lower binding was present in the ventromedial nucleus and median eminence. The results are consistent with the hypothesis that insulin modulates the neural regulation of feeding by acting at sites in the hypothalamus. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
