Adaptation to stress exposure prevents arrhythmogenic and contractural effects of the excess of Ca2+ on the heart by the increased activity of sarcoplasmic reticulum |
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| Authors: | Prof. Dr. F. Z. Meerson I. Yu. Malyshev T. G. Sazontova |
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| Affiliation: | (1) Present address: Institute of General Pathology and Pathological Physiology of the USSR AMS, Baltijskaya 8, 125315 Moscow, USSR |
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| Abstract: | Summary Adaptation of rats to repcated short-term stress exposure prevents, to a considerable extent, contractural and arrhythmogenic effects of high concentrations of extracellular Ca2+ on isolated heart. Increased efficiency of SR Ca2+-pump functioning and a significant increase in Ca2+ pump resistance to autolysis are proved to play the main role in this effect. |
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| Keywords: | antiarrhythmic effect stress-limiting mechanisms sarcoplasmic reticulum Ca2+ transport |
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