不同剂量法莫替丁治疗幽门螺杆菌阳性的十二指肠球部溃疡疗效对比研究

目的]观察不同剂量法莫替丁对H.Pyroli阳性的十二指肠球部溃疡(DU)的疗效。 方法]H.Pyroli阳性的:DU60例,随机分为3组,A组:奥美拉唑20 mg,2次／d:羟氨苄青霉素1 000 mg,2次／d:甲硝唑400 mg,2次／d;疗程7d,第2 w开始奥美拉唑20 mg,1次／d,总疗程28 d。B组:法莫替丁20 mg早上,40 mg晚上,1次／d,疗程28 d;羟氨苄青霉素1 000 mg,2次／d;呋喃唑酮100 mg,2次／d,疗程7 d。C组:法莫替丁20 mg,2次／d,疗程28 d,抗生素使用同B组。观察H.Pyroli根除情况、溃疡愈合情况、腹痛缓解情况及不良反应。结果]溃疡愈合率A、B、C 3组分别为91.7％、87.1％和64.3％,H.Pyroli根除率分别为91.7％、90.3％和67.9％,A组与C组、B组与C组之间两项均有显著性差异(P<0.05),A、B两组间两项均无显著性差异。结论]法莫替丁60 mg/d为基础的三联疗法治疗H.Pyroli相关性DU具有疗效高、价格低、副作用小的优点。

Comparision study on treating H.Pyroli related duodenal ulcer with different dose famotidine

Objective] To observe the efficacies of different dose Famotidine in treating duodenal ulcer (DU) with H.Pyroli positive in 60 patients. Methods] The 60 patients suffering from duodenal ulcer with H.Pyroli positive were divided into 3 groups randomly. Group A: Omeprazole 20 mg bid, Amoxicilin 1 000 mg bid, Metronidazole 400 mg bid for 7 days and Omeprazole 20 mg qd for 21 days; Group B: Famotidine 20 mg qm, 40 mg qn for 28 days, Amoxicilin 1 000 mg bid and Furazolidone 100 mg bid for 7 days; Group C: Famotidine 20 mg bid for 28 days, the use of antibiotic were the same as those of Group B; results of H.Pyroli eradication, the status of ulcer healing, clinical symptoms and side effects were observed and recorded. Results] The healing rates of DU in 3 groups were 91.7%, 87.1% and 64.3% respectively, the H.Pyroli eradication rates were 91.7%, 90.3% and 67.9% in group A, B and group C respectively , there were significient differences between group A, B and group C in ulcer healing rate ( P < 0.05) and H.Pyroli eradication (P<0.05), between group A and B were not statistically significant (P>0.05), mild side effects noted in all 3 grous, but they did not interfere treatment. Conclusion] Group B (Famotidine 60 mg/d) possesses the advantages of high efficacy, little side effects and cheap in cost, and that it is worth extending the use in this field.