| 表皮生长因子受体与雌,孕激素受体在乳腺癌组织中的表达及相互关系 |
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| 引用本文： | 丁秀敏,郎义芳.表皮生长因子受体与雌,孕激素受体在乳腺癌组织中的表达及相互关系[J].放射免疫学杂志,1998,11(1):4-6. |
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| 作者姓名： | 丁秀敏 郎义芳 |
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| 作者单位： | 天津市肿瘤研究所!300060(丁秀敏，何振祥)，天津市肿瘤医院(郎义芳) |
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| 摘 要： | 本文应用碘标记的表皮生长因子，用分步离心提取部细胞膜蛋白，以标准的ＥＧＦ作竞争剂，采取放射标记结合法测定了４０例乳腺癌组织中的表皮生长因子受体水平，同时采用葡聚糖活性碳分析法测定了乳腺癌组织中的雌激素受体，孕激素受体以探讨ＥＧＦＲ表达与ＥＲ，ＰＲ在乳腺癌组织中的生物学行为及相互关系。
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| 关 键 词： | 表皮生长因子 雌激素受体 孕激素受体 乳腺癌 |
EXPRESSION AND INTER-RELATIONSHIP BETWEEN EPIDERMAL GROWTH FACTOR AND ESTROGEN PROGESTERONE RECEPTORS IN BREAST CANCER TISSUE |
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| Ding Xiumin,He Zhenxiang,Lang Yifang Tianjing Cancer Hospital and Institute,Tianjin.EXPRESSION AND INTER-RELATIONSHIP BETWEEN EPIDERMAL GROWTH FACTOR AND ESTROGEN PROGESTERONE RECEPTORS IN BREAST CANCER TISSUE[J].Journal of Radioimmanology,1998,11(1):4-6. |
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| Authors: | Ding Xiumin He Zhenxiang Lang Yifang Tianjing Cancer Hospital and Institute Tianjin |
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| Institution: | Ding Xiumin,He Zhenxiang,Lang Yifang Tianjing Cancer Hospital and Institute,Tianjin 300060 |
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| Abstract: | The aim of the study was to quantitate the RFG binding to breast cancer tissue and compare with that of oestrogen, and progesterone. EGFR, ER, PR concentrations were determined by radioligand bind assay in 40 specimens of primary breast cancer tissue taking values>10 fmol/mg membrance protein to be positive for each of the parameters. EGRF levels were found to be 1-183 fmol/mg, and positive rate were 42.5%; positive rate for GR was 55% and22.5% for PR. found to be. There was no correlation between EGFR and histology type of breast cancer. However, there seemed to be an inverse relationship between ER( + ),PR( + ) group and EGFR( - ) group. Single ER( + ) group also had inverse relationship with EGFR( - ) group. Our data suggest that high levels of ER may inhibite the express of EGFR in breast cancetissue. The findings need further investigation. |
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| Keywords: | EGFR ER PR Radioligand Bind Assay Breast Cancer |
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