| 生长抑素对急性胃粘膜损伤保护作用的实验研究 |
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| 引用本文： | 李平,许国铭,王成海. 生长抑素对急性胃粘膜损伤保护作用的实验研究[J]. 南方医科大学学报, 1997, 0(1) |
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| 作者姓名： | 李平 许国铭 王成海 |
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| 作者单位： | 第二军医大学长海医院消化内科!上海，200433(李平，许国铭)，第二军医大学基础医学部神经生物学教研室(王成海) |
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| 摘 要： | 为建立癌胚抗原（CEA）尼龙微球固相免疫放射分析法并应用于临床．采用Lodogen法125Ⅰ标记CEA单克隆抗体C－17，用单克隆抗体C－50、C－6化学包被尼龙微球制成固相抗体（N－SP）．建立一步法的CEAN－SPIRMA，灵敏度2μg／L，工作范围为5－80μg／L，批内和批间CV分别为4．63％和8．34％，回收率93．86－104．73％．结果：65例正常人CEA值为5．2±3．8μg／L，78例良性病人为12．3±5．4μg／L，87例恶性肿瘤病人为69．3±51．4μg／L．正常组与良性疾病组比较差异无显著意义（P＞0．05）；正常组与恶性肿瘤组比较差异有显著意义（P＜0．01），以上测定值与CEA放射免疫法结果比较相关系数r＝0.9328，P＜0．01，且提高了恶性肿瘤诊断率．结论：该方法操作简便、快速、准确，是一种新型有效而实用的分析技术，可推广使用．
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| 关 键 词： | 生长抑素 急性胃粘膜损伤 细胞保护 |
The protective effects of somatostatin on acute gastric mucosal lesion in rats by pure alcohol |
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| Li Ping, Xu Guoming, Wang Chenghai. The protective effects of somatostatin on acute gastric mucosal lesion in rats by pure alcohol[J]. Journal of Southern Medical University, 1997, 0(1) |
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| Authors: | Li Ping Xu Guoming Wang Chenghai |
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| Abstract: | To observe the protective effect of somatostatin (SS) on gastric mucosa of rats.Methods: Before gastric mucosal lesion were made in rats by pure alcohol, SS was intravenously droppedand anti-SS serum was injected into the vein, and the change of ulcer index and the degree of gastric mu-cosal lesion were observed. Results: Ulcer index of the SS group was much lower than that of the controlgroup (P<0. 01) and the anti-SS group (P<0.01 ),and the ulcer index of the anti-SS serum group washigher than that of the control group (P<0. 05). The degree of gastric mucosal lesion 0f the anti-SSserum group was severer than that of the control group (P<0. 05),and the degree of gastric mucosal le-sion of the SS group was much milder than that of the anti-SS serum group (P<0. 01 ). Conclusion: SShas a protective effect on gastric mucosa of rats. |
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| Keywords: | somatostatin acute gastric lesion cytoprotection |
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