基质金属蛋白酶在胃间质瘤中的表达及其临床意义

目的研究基质金属蛋白酶（MMP）在胃间质瘤（GST）中的表达及其临床意义。方法采用免疫组化方法检测44例GST组织中的MMP-2、MMP-9的表达情况,并分析其与GST临床病理之间的关系。结果GST组织中的MMP-2、MMP-9阳性率分别为84．1％、81．8％,MMP-2、MMP-9随着GST恶性程度增高,其表达出现递增趋势（P〈0．05）,与肿瘤良恶性、生长方式、肿瘤大小、肿瘤中心有无坏死亦有明显关系（P均〈0．05）。MMP-2与MMP-9在GST中的表达阳性率呈明显正相关关系（r=0．6523,P〈0．05）。MMP-2、MMP-9阳性表达者5年生存率显著低于阴性表达者（P均〈0．05）。结论MMP-2、MMP-9在GST中的表达可以作为判断其性质、恶性程度、转移及预后的客观指标。

Expression and clinical significance of matrix metalloproteinase in gastric stromal tumor

OBJECTIVE: To investigate the expression and clinical significance of matrix metalloproteinase (MMP) in gastric stromal tumor (GST). METHODS: MMP-2 and MMP-9 expression were determined by immunohistochemistry in tumor tissues in 44 patients with GST, and their relationship with clinicopathologic factors of the neoplasm was also investigated. RESULTS: MMP-2 and MMP-9 were expressed in the cytoplasm in 84.1% (37/44) and 81.8% (36/44) of tumors, respectively. The positive rates of MMP-2 and MMP-9 increased significantly in parallel to the increase in tumor malignancy (P < 0.05) and associated with pattern of tumor growth, tumor size, and centre necrosis (P < 0.05). In addition, there was a statistically significant positive correlation between the expression of the two markers in GST (r = 0.6523, P < 0.05). Furthermore, the 5-year postoperative survival rates of patients with positive expressions of MMP-2 and MMP-9 were significantly lower than those of patients with negative expressions of the two markers (P < 0.05). CONCLUSION: Overexpressions of MMP-2 and MMP-9 can be served as objective markers to judge the malignant degree and, to predict the prognosis of patients with GST.