血管内皮生长因子C在喉鳞癌中的表达

目的 了解血管内皮生长因子C(VEGF-C)在喉鳞癌中的表达及其与淋巴结转移的关系。方法 采用免疫组化方法检测60例喉鳞癌患者术后肿瘤组织石蜡标本的VEGF-C蛋白的表达。结果 在部分喉鳞癌患者的癌细胞胞浆中可检测到VEGF-C蛋白的表达(45／60)。且VEGF-C蛋白的表达在有淋巴结转移的喉鳞癌组织中明显高于无淋巴结转移组织，在低分化喉鳞癌组织中的表达明显高于高、中分化喉鳞癌组织。结论 VEGF-C表达于喉癌中，其表达与喉癌细胞的淋巴结转移密切相关。

Expression of Vascular Endothelial Growth Factor C in Laryngeal Squamous Carcinoma and Its Role in Lymphatic Metastasis

Objective To study the expression of vascular endothelial growth factor C (VEGF-C) in laryngeal squamous carcinoma (LSC) and its relationship to lymph node metastasis. Methods Paraffin-embedded specimens of primary laryngeal carcinomas from 60 patients subjected to operation were studied. VEGF-C expression was investigated using immunohistochemical staining. Results Positive immunohistochemical staining for VEGF-C protein was observed in some laryngeal squamous carcinoma cells (45/60), the VEGF-C antigen was identified in the cytoplasm of cancer cells. Furthermore, the expression of VEGF-C in laryngeal squamous carcinoma cells was significantly higher in lymph-node-positive groups than in node-negative groups, and the expression was significantly higher in poorly differentiated LSC tissues than in moderately and well differentiated LSC tissues. Conclusion The above findings indicate a close correlation between VEGF-C expression and lymph node metastasis in laryngeal squamous carcinoma.