重症急性胰腺炎的早期个体化综合治疗--附110例分析

目的探讨重症急性胰腺炎（SAP）早期病情加重的危险因素，以微创介入技术及脏器功能支持技术为保障，个体化综合治疗早期SAP，降低SAP的病死率。方法回顾性分析安徽省立医院1995—1999年收治的53例SAP患者（第1组）和2000-2005年收治的57例SAP患者（第2组）临床资料，对患者Ranson评分、急性生理学与慢性健康状况评分Ⅱ（APACHEⅡ）、Balthazar CT分级以及是否伴有胆道梗阻、休克、高脂血症、腹腔间隙综合征、低氧血症、肺部感染、胸腔积液等因素进行多因素Logistic回归分析，分析不同治疗方法对并发症发生率和病死率的影响。结果两组中分别有13例和14例SAP患者早期并发多器官功能障碍综合征（MODS），MODS组和无MODS组比较，Ranson评分、APACHEⅡ评分和Balthazar CT分级差异均有显著性（P均〈0．05）。与第1组比较，第2组患者由于采用了综合性救治技术如床旁血液净化、人工肝支持治疗等，其病死率下降，差异有显著性（P〈0．05或P〈0．01）。结论SAP患者早期并发MODS的发生率及病死率与临床处理方式有关。对SAP患者进行个体化综合治疗有助于减少并发症及病死率。

Individualized and comprehensive therapy for severe acute pancreatitis in early stage: analysis of 110 cases

OBJECTIVE: To investigate the risk factors of exacerbation of severe acute pancreatitis (SAP) in early stage, in order to formulate therapeutic strategies including minimally invasive intervention and organ support, and to finalize an individualized and comprehensive therapy for the SAP in early stage to decrease the mortality. METHODS: Fifty-three patients with SAP admitted from 1995 to 1999 was categorized as group 1, and 57 patients admitted from 2000 to 2005 as group 2, were analyzed retrospectively. Ranson's score, acute physiological and chronic health evaluation II (APACHE II) score, Balthazar CT grade, presence or absence of biliary tract obstruction, hypoxia, lung infection, shock, abdomen compartment syndrome (ACS), hyperlipemia, pleural effusion were analysed logistically. Mortality following different treatments and incidence rate of complications were also evaluated. RESULTS: In the two groups, 13 patients of the group 1 and 14 of group 2 were complicated with multiple organ dysfunction syndrome (MODS) in the early stage. There was difference in Ranson's score, APACHE II, Balthazar CT grade, between the groups with and without MODS (all P<0.05). Higher incidences of shock, biliary tract obstruction, ACS, hyperlipemia, pleural effusion were seen in group with MODS (P<0.01). Mortality of group 2 patients was lowered after receiving a comprehensive therapy including bedside hemodialysis (CBP) and artificial liver support (P<0.01). CONCLUSION: Development of MODS in SAP and its mortality are related to strategies of treatment, and adoption of an individualized and comprehensive therapy for the SAP in early stage can decrease the complications and the mortality.